Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, Brazil.
Vet Microbiol. 2013 Oct 25;166(3-4):690-3. doi: 10.1016/j.vetmic.2013.07.024. Epub 2013 Aug 2.
Data regarding the susceptibility of Conidiobolus lamprauges is limited and there is no consensus about the optimal treatment for infections caused by Conidiobolus spp. In this context, the objective of this study was to evaluate the in vitro susceptibility of six C. lamprauges strains isolated from sheep conidiobolomycosis to amphotericin B, ketoconazole, fluconazole, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, flucytosine, and terbinafine using the CLSI M38-A2 microdilution technique. Terbinafine was the most active (MIC range <0.06-0.5 μg/mL). Resistance or reduced susceptibility was observed for amphotericin B and azole and echinocandin antifungals. Additional studies are necessary to determine the therapeutic potential of terbinafine as monotherapy or in combination therapy with other antifungals.
有关 Lamprauges 拟青霉易感性的数据有限，对于由拟青霉属 spp. 引起的感染的最佳治疗方法尚无共识。在这种情况下，本研究的目的是使用 CLSI M38-A2 微量稀释技术评估从绵羊拟青霉病中分离出的 6 株 Lamprauges 拟青霉对两性霉素 B、酮康唑、氟康唑、伊曲康唑、泊沙康唑、伏立康唑、阿尼芬净、卡泊芬净、米卡芬净、氟胞嘧啶和特比萘芬的体外敏感性。特比萘芬的活性最强（MIC 范围 <0.06-0.5 μg/mL）。两性霉素 B 和唑类及棘白菌素类抗真菌药的耐药性或敏感性降低。需要进一步研究以确定特比萘芬作为单一疗法或与其他抗真菌药联合治疗的治疗潜力。
