Jaffey Jared A, Hostnik Eric T, Hoffman Aline Rodrigues, Jay Maureen, Ferguson Sylvia H, Wiederhold Nathan P
Department of Specialty Medicine, Midwestern University College of Veterinary Medicine, Glendale, AZ, United States.
Department of Veterinary Clinical Sciences, Veterinary Medical Center, Ohio State University, Columbus, OH, United States.
Front Vet Sci. 2021 Feb 5;8:633695. doi: 10.3389/fvets.2021.633695. eCollection 2021.
This is a case of rhinitis in a Goldendoodle, that was presented for evaluation of sneezing, coughing, lethargy, as well as right-sided epistaxis and clear ocular discharge. Computed tomography revealed a large amount of soft tissue within the right nasal passage that obscured the osseous turbinates from the right maxillary canine tooth to the right side of the choanae. Biopsies revealed eosinophilic granulomas with variable number of basophilic to negatively staining, septate, fungal hyphae with non-parallel walls and irregular branching that were subsequently determined to be via panfungal PCR and sequencing. Complete and sustained resolution of clinical disease was achieved after 75 days of systemic antifungal therapy. This report describes for the first time, important clinical features of a dog with nasal conidiobolomycosis that will facilitate its recognition, prognostication, and treatment in clinical practice.
这是一例金毛寻回犬与贵宾犬杂交后代患鼻炎的病例，该犬因打喷嚏、咳嗽、嗜睡、右侧鼻出血及清亮眼部分泌物前来评估。计算机断层扫描显示右侧鼻腔内有大量软组织，从右上颌犬齿至后鼻孔右侧遮挡了骨性鼻甲。活检显示嗜酸性肉芽肿，伴有数量不等的嗜碱性至负染、有隔、壁不平行且分支不规则的真菌菌丝，随后通过泛真菌聚合酶链反应和测序确定了这些菌丝。经过75天的全身抗真菌治疗，临床疾病实现了完全且持续的缓解。本报告首次描述了犬鼻孢子丝菌病的重要临床特征，这将有助于在临床实践中对其进行识别、预后评估及治疗。
