Department of Nutritional Sciences, Logan University, Chesterfield, MO, USA.
Ann Epidemiol. 2013 Sep;23(9):564-70. doi: 10.1016/j.annepidem.2013.07.003.
To estimate the effects of calcium or vitamin D supplementation or a combination of both on blood pressure and serum lipid and carotenoid levels.
Ninety-two colorectal adenoma patients were randomized in a pilot, double-blind, placebo-controlled clinical trial of supplemental vitamin D3 800 IU and elemental calcium 2.0 g (as calcium carbonate) alone or in combination in divided doses twice daily with meals over 6 months.
Relative to placebo, mean serum triglycerides decreased 30% (P = .10) and 32% (P = .10) in the calcium and calcium plus vitamin D3 treatment groups, respectively. When the two calcium intervention groups were pooled and compared with the pooled noncalcium groups, the estimated supplemental calcium treatment effects were statistically significant for triglycerides (P = .04). Similar but nonstatistically significant decreases (5%-7%) were observed for serum total cholesterol levels. Mean systolic blood pressure increased 6% (P = .08) in the calcium group; otherwise, there were no appreciable changes in systolic or diastolic blood pressures in any active treatment group. Mean serum total carotenoid levels decreased 14% (P = .07) in the calcium and 9% (P = .10) in the calcium plus vitamin D3 groups.
Our results suggest that supplemental calcium alone or combined with vitamin D3 but not vitamin D3 alone may reduce serum lipids and lipophilic micronutrients.
评估钙或维生素 D 补充剂或两者联合应用对血压及血清脂质和类胡萝卜素水平的影响。
92 例结直肠腺瘤患者参与了一项先导性、双盲、安慰剂对照的临床试验，随机分为单独补充维生素 D3800IU 和元素钙 2.0g（碳酸钙）、或两者联合、分两次随餐服用，疗程 6 个月。
与安慰剂相比，钙组和钙+维生素 D3 组血清三酰甘油分别降低 30%（P=.10）和 32%（P=.10）。当两个钙干预组合并与非钙合并组比较时，补充钙治疗对三酰甘油的影响具有统计学意义（P=.04）。血清总胆固醇水平也观察到类似但无统计学意义的降低（5%-7%）。钙组收缩压升高 6%（P=.08）；而在任何活性治疗组中，收缩压或舒张压均无明显变化。钙组和钙+维生素 D3 组血清总类胡萝卜素水平分别降低 14%（P=.07）和 9%（P=.10）。
我们的结果表明，单独补充钙或与维生素 D3 联合补充钙，而不是单独补充维生素 D3，可能会降低血清脂质和脂溶性微量营养素水平。
