Department of Pediatrics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
Urology. 2013 Nov;82(5):1120-3. doi: 10.1016/j.urology.2013.05.047. Epub 2013 Aug 16.
To investigate the relation between copeptin, arginine vasopressin (AVP), and nocturnal enuresis (NE).
Forty-four patients with NE and 44 healthy children aged between 6 and 14 years were enrolled. Patients with nonmonosymptomatic and secondary NE were excluded from the study. A small questionnaire, filled by parents, collected information about sociodemographic characteristics. Blood was obtained for plasma AVP and copeptin concentrations.
Copeptin levels were significantly lower in patient group (3.74 ± 1.44 pg/mL) than the control group (16.57 ± 3.91 pg/mL), whereas AVP levels were not significantly different between groups. Copeptin levels were significantly lower in patients (3.17 ± 1.15 pg/mL) who had bed-wetting 2 or more nights a week, which is considered as severe bed-wetting, than the patients (4.95 ± 1.24 pg/mL) who had bed-wetting 1 night or less than 1 night a week.
This study demonstrates the presence of decreased levels of copeptin in patients with NE compared with healthy patients. AVP levels were not different between groups. To our knowledge, this is the first report assessing the relationship between copeptin and NE.
探讨 copeptin、精氨酸加压素（AVP）与夜间遗尿（NE）之间的关系。
纳入 44 例 NE 患者和 44 名年龄在 6 至 14 岁之间的健康儿童。排除非单症状性和继发性 NE 患者。家长填写一份小型问卷，收集社会人口统计学特征信息。采集血样，检测血浆 AVP 和 copeptin 浓度。
与对照组（16.57 ± 3.91 pg/mL）相比，患者组（3.74 ± 1.44 pg/mL）的 copeptin 水平显著降低，而两组之间的 AVP 水平无显著差异。每周尿床 2 次或以上（被认为是严重尿床）的患者（3.17 ± 1.15 pg/mL）的 copeptin 水平明显低于每周尿床 1 次或少于 1 次的患者（4.95 ± 1.24 pg/mL）。
与健康患者相比，本研究显示 NE 患者的 copeptin 水平降低。两组之间的 AVP 水平无差异。据我们所知，这是评估 copeptin 与 NE 之间关系的首次报告。
