PAX-8、CD5和CD117在鉴别胸腺癌与低分化肺癌中的作用。

Role of PAX-8, CD5, and CD117 in distinguishing thymic carcinoma from poorly differentiated lung carcinoma.

作者信息

Asirvatham Jaya R, Esposito Michael J, Bhuiya Tawfiqul A

机构信息

Department of Pathology, North Shore-Long Island Jewish Health System, NY.

出版信息

Appl Immunohistochem Mol Morphol. 2014 May-Jun;22(5):372-6. doi: 10.1097/PAI.0b013e318297cdb5.

DOI:10.1097/PAI.0b013e318297cdb5

PMID:23958552

Abstract

AIM

To determine if PAX-8, CD5, and CD117 can differentiate thymic carcinoma from poorly differentiated lung carcinoma.

DESIGN

Archived cases of thymic (n=13) and poorly differentiated lung (n=15) carcinoma were analyzed for intensity and proportion of expression of PAX-8, CD117, and CD5.

RESULTS

PAX-8 was positive in 69.2% of thymic and 5.8% of lung carcinomas. CD117 was positive in 84% of thymic and 26.6% of lung carcinomas. A total of 53% of thymic and none of the lung carcinomas were positive for CD5. Forty-six percent, 53%, and 69% of thymic carcinomas were dual positive for combinations of CD5/PAX-8, CD117/CD5, and CD117/PAX-8, respectively. None of the lung carcinomas were dual positive. Positivity for any 2 of the 3 markers was seen in 84% of thymic and none of the lung carcinomas. Triple positivity was seen in 53% of thymic carcinomas.

CONCLUSION

Adding PAX-8 to CD117 and CD5 increases the diagnostic yield for thymic carcinoma.

摘要

目的

确定PAX-8、CD5和CD117能否区分胸腺癌与低分化肺癌。

设计

对存档的胸腺癌病例（n = 13）和低分化肺癌病例（n = 15）分析PAX-8、CD117和CD5的表达强度及比例。

结果

PAX-8在69.2%的胸腺癌和5.8%的肺癌中呈阳性。CD117在84%的胸腺癌和26.6%的肺癌中呈阳性。53%的胸腺癌CD5呈阳性，而肺癌均为阴性。分别有46%、53%和69%的胸腺癌CD5/PAX-8、CD117/CD5和CD117/PAX-8组合呈双阳性。肺癌均无双阳性。84%的胸腺癌3种标志物中任意2种呈阳性，而肺癌均无。53%的胸腺癌呈三阳性。