Department of Biomedical Engineering, University of Wisconsin Madison, Wisconsin Institutes for Medical Research, 1111 Highland Ave., Madison, WI 53705, USA.
Acta Biomater. 2013 Dec;9(12):9270-80. doi: 10.1016/j.actbio.2013.08.011. Epub 2013 Aug 17.
A simple, degradable poly(ethylene glycol) (PEG) microsphere system formed from a water-in-water emulsion process is presented. Microsphere network degradation and erosion were controlled by adjusting the number of hydrolytically labile sites, by varying the PEG molecular weight, and by adjusting the emulsion conditions. Microsphere size was also controllable by adjusting the polymer formulation. Furthermore, it is demonstrated that alternative degradation and erosion mechanisms, such as proteolytic degradation, can be incorporated into PEG microspheres, resulting in mixed-mode degradation. Owing to the adaptability of this approach, it may serve as an attractive option for emerging tissue engineering, drug delivery and gene delivery applications.
本文介绍了一种简单的、可降解的聚乙二醇（PEG）微球体系，通过水包水乳液工艺形成。通过调整水解不稳定部位的数量、PEG 分子量和乳液条件来控制微球网络的降解和侵蚀。通过调整聚合物配方还可以控制微球的大小。此外，还证明了可以将替代的降解和侵蚀机制（如蛋白水解降解）纳入 PEG 微球中，从而导致混合模式降解。由于这种方法的适应性，它可能成为新兴的组织工程、药物输送和基因输送应用的一个有吸引力的选择。
