非血管药物洗脱支架作为局部药物控释平台：临床前和临床经验。

Non-vascular drug eluting stents as localized controlled drug delivery platform: preclinical and clinical experience.

机构信息

Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia.

Flinders Centre for Innovation in Cancer, Flinders University/Flinders Medical Centre, Medical Oncology, Bedford Park, Adelaide, SA 5042, Australia.

出版信息

J Control Release. 2013 Nov 28;172(1):105-117. doi: 10.1016/j.jconrel.2013.08.010. Epub 2013 Aug 17.

DOI:10.1016/j.jconrel.2013.08.010

PMID:23958902

Abstract

Stents occupy an important place in the medical field for their widespread application. They have been used in vascular as well as in non-vascular organs for various reasons. Among vascular stents, development of coronary drug eluting stents (DESs) has completely revolutionised the percutaneous coronary intervention. Similarly, attempts have been made to make use of this modality in non-vascular organs. This paper focuses on the preclinical and clinical experience with drug-eluting non-vascular stents with emphasis on drug delivery systems and regulatory requirements for their development.

摘要

支架在医学领域占有重要地位，因其应用广泛。出于各种原因，支架不仅用于血管，也用于非血管器官。在血管支架中，冠状动脉药物洗脱支架 (DES) 的发展彻底改变了经皮冠状动脉介入治疗。同样，人们也试图在非血管器官中利用这种方法。本文主要介绍药物洗脱非血管支架的临床前和临床经验，重点介绍药物输送系统及其开发的监管要求。