JAMA Neurol. 2013 Oct;70(10):1242-8. doi: 10.1001/jamaneurol.2013.3253.
Resting-state functional connectivity magnetic resonance imaging has great potential for characterizing pathophysiological changes during the preclinical phase of Alzheimer disease.
To assess the relationship between default mode network integrity and cerebrospinal fluid biomarkers of Alzheimer disease pathology in cognitively normal older individuals.
DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional cohort study at The Charles F. and Joanne Knight Alzheimer's Disease Research Center at Washington University in St Louis, St Louis, Missouri, among 207 older adults with normal cognition (Clinical Dementia Rating, 0).
Resting-state functional connectivity magnetic resonance imaging measures of default mode network integrity.
Decreased cerebrospinal fluid Aβ42 and increased cerebrospinal fluid phosphorylated tau181 were independently associated with reduced default mode network integrity, with the most prominent decreases in functional connectivity observed between the posterior cingulate and medial temporal regions. Observed reductions in functional connectivity were unattributable to age or structural atrophy in the posterior cingulate and medial temporal areas. Similar resting-state functional connectivity magnetic resonance imaging findings in relation to cerebrospinal fluid biomarkers were obtained using region-of-interest analyses and voxelwise correlation mapping.
Both Aβ and tau pathology affect default mode network integrity before clinical onset of Alzheimer disease.
静息态功能磁共振成像在阿尔茨海默病临床前阶段描述病理生理变化方面具有很大的潜力。
评估认知正常的老年人中默认模式网络完整性与阿尔茨海默病病理的脑脊液生物标志物之间的关系。
设计、地点和参与者：在密苏里州圣路易斯市华盛顿大学圣路易斯分校的 Charles F. 和 Joanne Knight 阿尔茨海默病研究中心进行的横断面队列研究，纳入 207 名认知正常的老年人（临床痴呆评定量表，0 分）。
静息态功能磁共振成像的默认模式网络完整性测量指标。
脑脊液 Aβ42 减少和脑脊液磷酸化 tau181 增加与默认模式网络完整性降低独立相关，在后扣带回和内侧颞叶区域之间观察到的功能连接下降最为明显。观察到的功能连接减少与后扣带回和内侧颞叶区域的年龄或结构萎缩无关。使用感兴趣区域分析和体素相关映射获得了与脑脊液生物标志物相关的类似静息态功能磁共振成像发现。
在阿尔茨海默病临床发病前，Aβ 和 tau 病理学均影响默认模式网络完整性。
