Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
Chem Soc Rev. 2014 May 7;43(9):2956-78. doi: 10.1039/c3cs60382b. Epub 2014 Feb 11.
The [2+2+1] cyclization of an alkyne, an alkene and carbon monoxide, i.e., the Pauson-Khand reaction, is one of the most powerful tools for constructing a five-membered ring. In place of the alkene or alkyne part, the use of an allene functionality has proven to make this reaction more valuable for organic synthesis. This review focuses on the origin and progress of the allenic [2+2+1] cyclocarbonylation, including the chirality transfer of the allene and its synthetic applications.
炔烃、烯烃和一氧化碳的[2+2+1]环化反应，即 Pauson-Khand 反应，是构建五元环的最有力工具之一。在烯烃或炔烃部分的位置上，使用丙二烯官能团已被证明使该反应对有机合成更有价值。本综述重点介绍了丙二烯[2+2+1]环羰化反应的起源和进展，包括丙二烯的手性转移及其合成应用。
