N-杂环卡宾催化的高对映选择性合成取代的二氢吡喃并吡唑酮。
N-heterocyclic carbene-catalyzed highly enantioselective synthesis of substituted dihydropyranopyrazolones.
机构信息
Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Org Biomol Chem. 2013 Oct 7;11(37):6255-7. doi: 10.1039/c3ob41455h.
PMID:23959516
Abstract
Highly optically pure multisubstituted dihydropyrano[2,3-c]pyrazol-6-(1H)-ones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of α-chloroaldehydes and pyrazolone-derived oxodienes.
摘要
通过 N-杂环卡宾催化的 α-氯代醛和吡唑啉酮衍生的氧二烯的对映选择性[4+2]环加成反应，合成了高光学纯的多取代二氢吡喃并[2,3-c]吡唑-6-(1H)-酮。
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