由氟化配体保护的金纳米颗粒用于 19F MRI。
Gold nanoparticles protected by fluorinated ligands for 19F MRI.
机构信息
Department of Chemical and Pharmaceutical Sciences, University of Trieste, 34127 Trieste, Italy.
出版信息
Chem Commun (Camb). 2013 Oct 9;49(78):8794-6. doi: 10.1039/c3cc44572k.
PMID:23959517
Abstract
Gold nanoparticles coated with fluorinated ligands (F-MPCs) present features suitable for (19)F MRI as observed from phantom experiments. Cellular uptake, by HeLa cells, and toxicity of fluorescent dye-decorated F-MPCs are presented together with their ability to bind hydrophobic molecules allowing for a potential combination of targeting, delivery and imaging features.
摘要
涂覆有氟化物配体的金纳米颗粒（F-MPCs）具有适合（19）F MRI 的特性，这一点从体模实验中可以观察到。本文展示了带荧光染料的 F-MPCs 的细胞摄取和毒性，以及它们与疏水分子结合的能力，这使其具有潜在的靶向、递药和成像特性的结合能力。
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