CNS Drugs. 2013 Nov;27(11):963-9. doi: 10.1007/s40263-013-0103-9.
Medication reconciliation results in fewer adverse drug events. The first step in medication reconciliation is to carry out a structured interview about medication use. It is not known whether such an interview is useful in inpatient old age psychiatry. The object of this study was to determine at admission the number of discrepancies in medication use, comparing the structured history of medication use (SHIM) procedure with the usual procedure for taking the medication history.
A prospective observational study was conducted. All consecutive patients aged 55 years and older admitted from January until April 2011 to the inpatient old age psychiatric clinic of a large psychiatric teaching hospital in The Hague, the Netherlands, were eligible for inclusion; 50 patients were included. In every patient, the usual procedure (medication history-taking at admission by the treating physician) was compared with the SHIM procedure administered by the researcher. The SHIM procedure consists of a structured interview with the patient about the actual use of medication, incorporating the information from the community pharmacy and the patient's medications brought to the interview. The main outcome was the number of discrepancies in recorded medication use between the SHIM and the usual procedure.
In total, 100 discrepancies (median 2 per patient, range 0-8) in medication use were identified; 78 % (n = 39) of the patients had at least one discrepancy. Of the discrepancies, 69 % were drug omissions, and 31 % were drug additions or discrepancies in the frequency or dosage of medications. Eighty-two percent of all discrepancies were potentially clinically relevant. In 24 % of the patients, the discrepancies had clinical consequences.
The number of discrepancies that were found suggests that the usual procedure for taking the medication history can be improved. The SHIM procedure enables a comprehensive and accurate overview of the medication used by older patients admitted to a psychiatric hospital, and contributes to the prevention of clinically relevant adverse drug events.
药物重整可减少药物不良事件。药物重整的第一步是进行关于用药情况的结构化访谈。这种访谈在老年精神病学住院患者中是否有用尚不清楚。本研究的目的是在入院时确定药物使用差异的数量,将药物使用结构化史(SHIM)程序与常规用药史采集程序进行比较。
前瞻性观察研究。2011 年 1 月至 4 月期间,荷兰海牙一家大型精神病学教学医院的老年精神病学住院病房连续收治的所有年龄 55 岁及以上的患者均符合入选条件,共纳入 50 例患者。每位患者均同时接受常规程序(入院时主治医生采集用药史)和研究者实施的 SHIM 程序。SHIM 程序包括对患者进行关于实际用药情况的结构化访谈,将社区药房的信息和患者带到访谈中的药物纳入其中。主要结局是 SHIM 和常规程序记录的用药差异数量。
共发现 100 处用药差异(中位数为每名患者 2 处,范围 0-8 处);78%(n=39)的患者至少存在一处差异。差异中,69%为药物漏用,31%为药物添加或药物使用频率或剂量差异。所有差异中有 82%潜在具有临床意义。24%的患者中,差异具有临床后果。
所发现的差异数量表明,常规的用药史采集程序可以得到改进。SHIM 程序可全面、准确地了解老年精神病学住院患者的用药情况,有助于预防具有临床意义的药物不良事件。