Kogure K, Busto R, Matsumoto A, Scheinberg P, Reinmuth O M
Am J Physiol. 1975 Jun;228(6):1862-7. doi: 10.1152/ajplegacy.1975.228.6.1862.
Hypocapnia of moderate and extreme degree (Paco2 21.1 and 13.5 torr, respectively)was induced by hyperventilation in rats subjected to the closed system of Lowry inorder to evaluate the effects on utilization rate of cerebral energy metabolites. The tissue levels of high-energy phosphates and calculated intracellular pH did not change, whereas glucose, pyruvate, and lactate increased significantly. The La/Pyratio and NADH/NAD-+ RATIO BOTH INCREASED IN PROPORTION TO THE DEGREE OF HYPOCAPNIA. Utilization rates of glucose, glycogen, and ATP were all significantly reduced by hypocapnia, whereas the utilization rate of phosphocreatine was increased. The rate oftotal high-energy phosphate use was also diminished in proportion to the degree of hypocapnia. The constant value of the energy charge (0.94 plus or minus 0.01) indicates that the energy production rate might also be reduced by hyperventilation; thus the intermediate metabolics and substrates increased. It is concluded that extreme hypocapnia reduces the rate of cerebral energy metabolism significantly.
为了评估对脑能量代谢物利用率的影响，在采用洛瑞封闭系统的大鼠中通过过度通气诱导中度和极度低碳酸血症（动脉血二氧化碳分压分别为21.1和13.5托）。高能磷酸盐的组织水平和计算出的细胞内pH值没有变化，而葡萄糖、丙酮酸和乳酸显著增加。乳酸/丙酮酸比值和NADH/NAD⁺比值均随低碳酸血症程度的增加而升高。低碳酸血症使葡萄糖、糖原和ATP的利用率均显著降低，而磷酸肌酸的利用率增加。总的高能磷酸盐使用速率也与低碳酸血症程度成比例降低。能量电荷的恒定值（0.94±0.01）表明过度通气可能也会降低能量产生速率；因此中间代谢物和底物增加。得出的结论是，极度低碳酸血症会显著降低脑能量代谢速率。
