人类冯·埃科诺莫神经元表达与第五层大脑皮质下投射神经元相关的转录因子。
Human von Economo neurons express transcription factors associated with Layer V subcerebral projection neurons.
作者信息
Cobos Inma, Seeley William W
机构信息
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA Current address: Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
出版信息
Cereb Cortex. 2015 Jan;25(1):213-20. doi: 10.1093/cercor/bht219. Epub 2013 Aug 19.
The von Economo neurons (VENs) are large bipolar Layer V projection neurons found chiefly in the anterior cingulate and frontoinsular cortices. Although VENs have been linked to prevalent illnesses such as frontotemporal dementia, autism, and schizophrenia, little is known about VEN identity, including their major projection targets. Here, we undertook a developmental transcription factor expression study, focusing on markers associated with specific classes of Layer V projection neurons. Using mRNA in situ hybridization, we found that VENs prominently express FEZF2 and CTIP2, transcription factors that regulate the fate and differentiation of subcerebral projection neurons, in humans aged 3 months to 65 years. In contrast, few VENs expressed markers associated with callosal or corticothalamic projections. These findings suggest that VENs may represent a specialized Layer V projection neuron for linking cortical autonomic control sites to brainstem or spinal cord regions.
冯·埃科诺莫神经元（VENs）是主要在前扣带回和额岛叶皮质中发现的大型双极V层投射神经元。尽管VENs已与诸如额颞叶痴呆、自闭症和精神分裂症等常见疾病相关联，但对于VENs的特征，包括其主要投射靶点，人们却知之甚少。在此，我们开展了一项发育转录因子表达研究，重点关注与特定类型V层投射神经元相关的标志物。利用mRNA原位杂交技术，我们发现，在3个月至65岁的人类中，VENs显著表达FEZF2和CTIP2，这两种转录因子可调节大脑皮质下投射神经元的命运和分化。相比之下，很少有VENs表达与胼胝体或皮质丘脑投射相关的标志物。这些发现表明，VENs可能代表一种特殊的V层投射神经元，用于将皮质自主控制位点与脑干或脊髓区域相连。
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