Nat Rev Neurosci. 2013 Nov;14(11):755-69. doi: 10.1038/nrn3586. Epub 2013 Oct 9.
The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of neuronal subtypes generated during development under precise molecular regulation. In recent years, several key controls over the specification and differentiation of neocortical projection neurons have been identified. This work provides substantial insight into the 'molecular logic' underlying cortical development and increasingly supports a model in which individual progenitor-stage and postmitotic regulators are embedded within highly interconnected networks that gate sequential developmental decisions. Here, we provide an integrative account of the molecular controls that direct the progressive development and delineation of subtype and area identity of neocortical projection neurons.
新皮层的复杂电路是由发育过程中在精确的分子调控下产生的多种神经元亚型组装而成的。近年来，已经确定了几个对新皮层投射神经元的特化和分化的关键控制。这项工作为皮层发育的“分子逻辑”提供了重要的见解，并越来越支持这样一种模型，即单个祖细胞阶段和有丝分裂后调节因子嵌入在高度相互连接的网络中，这些网络控制着顺序发育决策。在这里，我们提供了一个综合的分子控制的描述，这些控制指导了新皮层投射神经元的逐步发育和亚型及区域特征的划定。
