IgG4相关性间质性肾炎：一例报告并文献复习

Gopalakrishnan N, Abraham A, Balasubramaniyan T, Dineshkumar T, Dhanapriya J, Malathy N, Haris M, Prasad N D Srinivasa

Department of Nephrology, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, India.

Indian J Nephrol. 2013 Jul;23(4):308-11. doi: 10.4103/0971-4065.114489.

IgG4 interstitial nephritis is a recently described entity. A middle-aged gentleman with bilateral parotid enlargement, hepatosplenomegaly and generalized lymphadenopathy was referred to us for evaluation of renal failure. He had trace proteinuria and large kidneys. Kidney biopsy revealed interstitial nephritis with characteristic storiform fibrosis. Immunohistochemistry demonstrated intense staining for IgG4-secreting plasma cells in the interstitium.

IgG4相关性间质性肾炎是一种最近才被描述的疾病。一名患有双侧腮腺肿大、肝脾肿大和全身淋巴结病的中年男性因肾衰竭前来我们这里进行评估。他有微量蛋白尿和肾脏肿大。肾活检显示间质性肾炎伴有特征性的席纹状纤维化。免疫组织化学显示间质中分泌IgG4的浆细胞呈强阳性染色。