Dhurat Rachita, Sukesh Ms, Avhad Ganesh, Dandale Ameet, Pal Anjali, Pund Poonam
Department of Dermatology, L.T.M. Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.
Int J Trichology. 2013 Jan;5(1):6-11. doi: 10.4103/0974-7753.114700.
Dermal papilla (DP) is the site of expression of various hair growth related genes. Various researches have demonstrated the underlying importance of Wnt proteins and wound growth factors in stimulating DP associated stem cells. Microneedling works by stimulation of stem cells and inducing activation of growth factors.
Hundred cases of mild to moderate (III vertex or IV) androgenetic alopecia (AGA) were recruited into 2 groups. After randomization one group was offered weekly microneedling treatment with twice daily 5% minoxidil lotion (Microneedling group); other group was given only 5% minoxidil lotion. After baseline global photographs, the scalp were shaved off to ensure equal length of hair shaft in all. Hair count was done in 1 cm(2) targeted fixed area (marked with tattoo) at baseline and at end of therapy (week 12). The 3 primary efficacy parameters assessed were: Change from baseline hair count at 12 weeks, patient assessment of hair growth at 12 weeks, and investigator assessment of hair growth at 12 weeks. A blinded investigators evaluated global photographic response. The response was assessed by 7- point scale.
(1) Hair counts - The mean change in hair count at week 12 was significantly greater for the Microneedling group compared to the Minoxidil group (91.4 vs 22.2 respectively). (2) Investigator evaluation - Forty patients in Microneedling group had +2 to +3 response on 7-point visual analogue scale, while none showed the same response in the Minoxidil group. (3) Patient evaluation - In the Microneedling group, 41 (82%) patients reported more than 50% improvement versus only 2 (4.5%) patients in the Minoxidil group. Unsatisfied patients to conventional therapy for AGA got good response with Microneedling treatment.
Dermaroller along with Minoxidil treated group was statistically superior to Minoxidil treated group in promoting hair growth in men with AGA for all 3 primary efficacy measures of hair growth. Microneedling is a safe and a promising tool in hair stimulation and also is useful to treat hair loss refractory to Minoxidil therapy.
真皮乳头（DP）是各种与头发生长相关基因的表达部位。各种研究已经证明了Wnt蛋白和伤口生长因子在刺激与DP相关的干细胞方面的潜在重要性。微针疗法通过刺激干细胞并诱导生长因子的激活来发挥作用。
招募了100例轻度至中度（III级顶点或IV级）雄激素性脱发（AGA）患者，分为两组。随机分组后，一组接受每周一次的微针治疗，并每日两次使用5%米诺地尔洗剂（微针组）；另一组仅使用5%米诺地尔洗剂。在拍摄基线全局照片后，将头皮剃光，以确保所有患者的毛干长度相等。在基线和治疗结束时（第12周），在1平方厘米的目标固定区域（用纹身标记）进行毛发计数。评估的3个主要疗效参数为：12周时相对于基线毛发计数的变化、患者对12周时头发生长的评估以及研究者对12周时头发生长的评估。由一位盲法研究者评估全局照片反应。反应通过7分制进行评估。
（1）毛发计数——微针组在第12周时毛发计数的平均变化显著大于米诺地尔组（分别为91.4和22.2）。（2）研究者评估——微针组中有40名患者在7分视觉模拟量表上有+2至+3的反应，而米诺地尔组中没有患者有相同的反应。（3）患者评估——在微针组中，41名（82%）患者报告改善超过50%，而米诺地尔组中只有2名（4.5%）患者。对AGA传统治疗不满意的患者通过微针治疗获得了良好的反应。
对于AGA男性患者，在促进头发生长的所有3个主要疗效指标方面，微针滚轮联合米诺地尔治疗组在统计学上优于米诺地尔治疗组。微针疗法是一种安全且有前景的头发生长刺激工具，对米诺地尔治疗难治的脱发也有效。
