Reddy S, Andl T, Bagasra A, Lu M M, Epstein D J, Morrisey E E, Millar S E
Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Mech Dev. 2001 Sep;107(1-2):69-82. doi: 10.1016/s0925-4773(01)00452-x.
Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles for WNT proteins in this process. We show that expression of Wnts 10b and 10a is upregulated in placodes at the onset of follicle morphogenesis and in postnatal hair follicles beginning a new cycle of hair growth. The expression of additional Wnt genes is observed in follicles at later stages of differentiation. Among these, we find that Wnt5a is expressed in the developing dermal condensate of wild type but not Sonic hedgehog (Shh)-null embryos, indicating that Wnt5a is a target of SHH in hair follicle morphogenesis. These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis.
WNT效应基因的突变会扰乱毛囊形态发生，这表明WNT蛋白在此过程中发挥关键作用。我们发现，在毛囊形态发生开始时，Wnts 10b和10a在基板中表达上调，在开始新的毛发生长周期的产后毛囊中也上调。在分化后期的毛囊中观察到其他Wnt基因的表达。其中，我们发现Wnt5a在野生型胚胎发育中的真皮凝聚物中表达，但在音猬因子（Shh）基因敲除胚胎中不表达，这表明Wnt5a是毛囊形态发生中SHH的一个靶点。这些结果确定了几种关键毛囊信号的候选基因，并表明WNT和SHH信号通路相互作用以调节毛囊形态发生。
