Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India.
Saudi Pharm J. 2011 Oct;19(4):273-8. doi: 10.1016/j.jsps.2011.04.004. Epub 2011 May 4.
Accidental and intentional poisonings or drug overdoses constitute a significant source of aggregate morbidity, mortality, and health care expenditure. Studies evaluating drug related hospitalization have estimated that approximately 5-10% of all hospital admissions are drug related. The present study was carried out to investigate type, nature and incidence of drug related admissions in our hospital settings.
A hospital based retrospective study was conducted in 575 cases of drug related admissions. The case records of patients admitted in various clinical departments of Amrita Institute of Medical Sciences (AIMS) Hospital during last 8 years (January 2002-December 2009) were collected and analyzed.
During the retrospective study, the total number of drug related cases reported were 575. Out of these, 35.5% cases were induced by central nervous system (CNS) drugs, 19.8% were by cardiovascular system (CVS) drugs, 12.3% were by NSAIDs, 11.3% were by antibiotics and 9.9% were by anticoagulants, 11.3% by other drugs which includes hormones, cytotoxic drugs, hypolipidemics, etc. Four hundred and forty cases were admitted to emergency department. Common drug related problems resulting in hospital visits were due to intentional, accidental and overdose. The incidence of drug related hospital admissions was found to be 0.20%.
The most of the accidental and suicidal cases were reported are by CNS drugs. Psychiatric patients intentionally taking medicines as suicidal attempt and as a part of their illness. As drug related problems are so significant, increased awareness and enhanced collaborative efforts among patients, physicians, pharmacists and caregivers within community and hospital have the potential to minimize the impact of this problem.
意外中毒和故意服毒或药物过量是导致发病、死亡和医疗支出的主要原因。评估药物相关性住院治疗的研究估计，约有 5-10%的住院治疗是与药物相关的。本研究旨在调查我院药物相关性住院治疗的类型、性质和发生率。
对我院 575 例药物相关性住院治疗患者进行基于医院的回顾性研究。收集并分析了我院各临床科室（2002 年 1 月-2009 年 12 月）在过去 8 年期间收治的患者的病历记录。
在回顾性研究中，共报告了 575 例药物相关性病例。其中，35.5%的病例是由中枢神经系统（CNS）药物引起的，19.8%是由心血管系统（CVS）药物引起的，12.3%是由非甾体抗炎药（NSAIDs）引起的，11.3%是由抗生素引起的，9.9%是由抗凝剂引起的，11.3%是由其他药物引起的，包括激素、细胞毒性药物、降脂药等。440 例患者被收入急诊部。导致住院的常见药物相关问题是由于故意、意外和过量用药。药物相关性住院治疗的发生率为 0.20%。
报告的大多数意外和自杀病例都是由 CNS 药物引起的。精神病患者故意服用药物作为自杀企图和作为其疾病的一部分。由于药物相关问题非常严重，患者、医生、药剂师和护理人员在社区和医院内加强合作和提高认识，有可能最大限度地减少这一问题的影响。
