秋葵（Okra）：Hibiscus esculentus L.：其保肝活性的研究。
'Okra' Hibiscus esculentus L.: A study of its hepatoprotective activity.
机构信息
Department of Pharmacognosy, Medicinal, Aromatic and Poisonous Plants Research Centre (MAPPRC), College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
出版信息
Saudi Pharm J. 2012 Apr;20(2):135-41. doi: 10.1016/j.jsps.2011.10.002. Epub 2011 Nov 7.
Abstract
In the present study, an attempt has been made to validate the claimed uses of 'Okra' Hibiscus esculentus in liver diseases. The preventive action of ethanolic extract of okra (EEO) against liver injury was evaluated in rodents using carbon tetrachloride-induced hepatotoxicity model. EEO, at 250 and 500 mg/kg body weight, exerted significant dose-dependent hepatoprotection by decreasing the CCl4-induced elevation of serum SGOT, SGPT, ALP, GGT, cholesterol, triglycerides and malondialdehyde (MDA) non-protein sulfhydryls (NP-SH) and total protein (TP) levels in the liver tissue. A significant reduction was also observed in pentobarbital-induced sleeping time in mice. The hepatoprotective and antioxidant activities of the extract are being comparable to standard silymarin. These findings were supported by histological assessment of the liver biopsy. The ability of okra extract to protect chemically induced liver damage may be attributed to its potent antioxidant property.
摘要
在本研究中，我们试图验证“秋葵”（Hibiscus esculentus）在肝脏疾病中的应用。使用四氯化碳诱导的肝毒性模型，评估了秋葵乙醇提取物（EEO）对肝脏损伤的预防作用。EEO 在 250 和 500mg/kg 体重时，通过降低 CCl4 诱导的血清 SGOT、SGPT、ALP、GGT、胆固醇、甘油三酯和丙二醛（MDA）非蛋白巯基（NP-SH）和肝组织总蛋白（TP）水平，表现出显著的剂量依赖性肝保护作用。在小鼠中，戊巴比妥诱导的睡眠时间也显著减少。提取物的保肝和抗氧化活性与标准水飞蓟素相当。这些发现得到了肝活检组织学评估的支持。秋葵提取物能够保护化学诱导的肝损伤，这可能归因于其强大的抗氧化特性。
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