Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Orissa, India.
Saudi Pharm J. 2013 Jan;21(1):113-7. doi: 10.1016/j.jsps.2011.11.002. Epub 2011 Nov 22.
Hydrodynamically balanced systems (HBSs) of ofloxacin were prepared using lactose, HPMC K4M, PVP K 30, and liquid paraffin, which may increase the mean residence time in the gastrointestinal tract, and may be able to provide maximum drug at the site of absorption to improve oral bioavailability. All these formulated HBS capsules were floated well over 6 h with no floating lag time. They also showed sustained drug release over 6 h. Time for 50% release of ofloxacin was within the range, 2.47 ± 0.02 to 3.07 ± 0.08 h. The in vitro drug release from these HBS capsules was dependent on HPMC K4M, PVP K 30, and liquid paraffin content. The drug release pattern of these HBS capsules containing ofloxacin followed the Higuchi model with the anomalous transport mechanism.
制备了以乳糖、HPMC K4M、PVP K30 和液体石蜡为载体制备的氧氟沙星流体动力学平衡系统（HBS），这可能会增加在胃肠道中的平均驻留时间，并可能能够在吸收部位提供最大药物浓度，从而提高口服生物利用度。所有这些包封的 HBS 胶囊在 6 小时以上的时间内均能很好地漂浮，且无漂浮迟滞时间。它们还表现出 6 小时以上的药物持续释放。氧氟沙星的 50%释放时间在 2.47±0.02 至 3.07±0.08 小时范围内。这些 HBS 胶囊中氧氟沙星的体外释放依赖于 HPMC K4M、PVP K30 和液体石蜡的含量。这些含有氧氟沙星的 HBS 胶囊的药物释放模式符合 Higuchi 模型，具有异常传输机制。
