Chowdary Kora Pattabhi Rama, Rao Yarraguntla Srinivasa
Industrial Pharmacy Division, Department of Pharmaceutical Sciences, Andhra University, AP India.
Biol Pharm Bull. 2004 Nov;27(11):1717-24. doi: 10.1248/bpb.27.1717.
Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive micro-spheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. The objective of this article is review the principles underlying the development and evaluation of mucoadhesive microspheres and the research work carried out on these systems.
粘膜粘附是当前药物递送系统设计中备受关注的一个话题。粘膜粘附微球在应用或吸收部位具有较长的停留时间，并有助于与下方的吸收表面紧密接触，从而有助于提高药物的治疗性能和/或使其具有更好的治疗效果。近年来，已经开发出了这种粘膜粘附微球，用于口服、颊部、鼻腔、眼部、直肠和阴道给药途径，以产生全身或局部作用。本文的目的是综述粘膜粘附微球开发和评价的基本原理以及在这些系统上开展的研究工作。
