College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Saudi Pharm J. 2013 Jan;21(1):119-21. doi: 10.1016/j.jsps.2012.02.003. Epub 2012 Feb 23.
Microbial pathogens develop resistance to a particular antibiotic after repeated administration during the treatment of infectious diseases. Moreover, multiple drug resistance is a very common problem especially in hospital acquired infections. Therefore, it is necessary to find out alternative antibacterial drugs and the present trend is focused on seaweeds. This preliminary research work was carried out to find out the antibacterial activity of petroleum ether extract of Chaetomorpha antennina. The extracts were tested against Staphylococcus aureus MTCC 121, Bacillus cereus MTCC 492, Bacillus subtilis MTCC 441, Klebsiella pneumoniae MTCC 530, Escherichia coli MTCC 443 and Pseudomonas aeruginosa MTCC 779 by agar well diffusion technique. It was observed that petroleum ether extract showed prominent zone of inhibition against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus even at 50 μg/ml concentration. The maximum spectrum of activity was observed against Staphylococcus aureus ranged from 7.3 ± 0.8 to 18 ± 2.4 mm at the concentration 50 to 500 μg/ml, respectively. Hence the most susceptible bacterium was Staphylococcus aureus among the tested organisms. However, Escherichia coli and Pseudomonas aeruginosa are also susceptible. But the Bacillus cereus and Klebsiella pneumoniae are resistant against the tested extract.
微生物病原体在治疗传染病时，经过多次重复给药后会对特定抗生素产生耐药性。此外，多重耐药性是一个非常普遍的问题，特别是在医院获得性感染中。因此，有必要寻找替代的抗菌药物，目前的趋势是关注海藻。这项初步研究旨在发现 Chaetomorpha antennina 石油醚提取物的抗菌活性。通过琼脂孔扩散技术，将提取物测试了金黄色葡萄球菌 MTCC 121、蜡状芽孢杆菌 MTCC 492、枯草芽孢杆菌 MTCC 441、肺炎克雷伯菌 MTCC 530、大肠杆菌 MTCC 443 和铜绿假单胞菌 MTCC 779。结果表明，石油醚提取物在 50μg/ml 浓度下对大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌表现出明显的抑制作用。在 50 至 500μg/ml 的浓度范围内，对金黄色葡萄球菌的最大活性谱观察到 7.3±0.8 至 18±2.4mm。因此，在所测试的生物体中，最敏感的细菌是金黄色葡萄球菌。然而，大肠杆菌和铜绿假单胞菌也容易受到影响。但是，蜡状芽孢杆菌和肺炎克雷伯菌对测试提取物具有抗性。
