Yanamandra Uday, Jairam Anantharam, Kotwal Narendra, Venkata Baliga Krishna, Nair Velu
Department of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra, India.
Indian J Endocrinol Metab. 2013 Jul;17(4):747-50. doi: 10.4103/2230-8210.113775.
Acromegaly a common pituitary disorder has significant adverse effects on well-being and survival. The slight increase in the prevalence of hypertension in acromegaly is well known and is proposed to be the direct effects of growth hormone. The hypertension for calculating the prevalence in most series was defined as diastolic more than 100 mmHg, but hypertensive emergency is rarely ever described in the literature. Growth hormone excess has been associated with renal manifestations such as hypercalciuria and nephrolithiasis, but never with renal failure. We present a case referred to a tertiary care nephrology center with malignant hypertension. This is the first case of a patient of acromegaly presenting with hypertensive emergency progressing to malignant nephrosclerosis and renal failure.
肢端肥大症是一种常见的垂体疾病,对健康和生存有显著的不良影响。肢端肥大症患者高血压患病率略有上升是众所周知的,并且被认为是生长激素的直接作用。大多数研究系列中计算患病率时,高血压被定义为舒张压超过100 mmHg,但文献中很少描述高血压急症。生长激素过多与高钙尿症和肾结石等肾脏表现有关,但从未与肾衰竭有关。我们报告一例转诊至三级医疗肾脏病中心的恶性高血压病例。这是首例肢端肥大症患者出现高血压急症并进展为恶性肾硬化和肾衰竭的病例。