Bloomberg School of Public Health, Johns Hopkins University, Baltimore.
J Infect Dis. 2014 Feb 1;209(3):355-9. doi: 10.1093/infdis/jit444. Epub 2013 Aug 20.
To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P = .01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10(-4)), as was one 81-kb haplotype (adjusted P = .0006). The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of African descent.
为了确认先前在非洲裔和欧洲裔个体中与丙型肝炎病毒（HCV）持续感染相关的 HAVCR1 多态性，我们研究了 165 名非洲裔个体和 635 名欧洲裔个体。由于该关联仅在非洲裔个体中得到确认（rs6880859；比值比，2.42；P =.01），我们随后使用 379 名非洲裔个体（142 名自发清除 HCV）对 HAVCR1 进行精细映射。rs111511318 在调整 IL28B 和 HLA 后与 HCV 持续感染强烈相关（调整后 P = 8.8×10(-4)），81-kb 单倍型也是如此（调整后 P =.0006）。HAVCR1 基因组区域是非洲裔个体中 HCV 持续感染的独立遗传决定因素。
