Brailski Kh, Mendizova A, Dimitrov B
Vutr Boles. 1990;29(1):25-30.
30 patients with endoscopically proved duodenal peptic ulcer were treated with Bulgarian drug Ranatidin in a dose of 150 mg twice daily in the course of 20 days. The pains were relieved up to the third day in 90% of the patients treated and the dyspeptic complaints disappeared in 1-3 days in 96-100% of the patients. Following the treatment course a statistically significant decrease of the gastric secretion indices was established (V, V1) and of the basic acid production (BAO, MAO, PAO) in comparison with the values before the treatment. Full epithelialization of the ulcer was found endoscopically in 60% of the patients treated and in the remaining 40% the size of the ulcer has diminished. The ulcer epithelialization is related to its initial size. The results achieved do not differ from those achieved with the analogous English drug Zantac. No side effects were observed in the course of treatment with Ranatidin.
30例经内镜证实为十二指肠消化性溃疡的患者，接受保加利亚药物雷尼替丁治疗，剂量为每日2次，每次150毫克，疗程20天。在接受治疗的患者中，90%的患者疼痛在第三天得到缓解，96 - 100%的患者消化不良症状在1 - 3天内消失。与治疗前的值相比，治疗后胃液分泌指标（V、V1）以及基础胃酸分泌量（BAO、MAO、PAO）有统计学意义的下降。经内镜检查发现，60%接受治疗的患者溃疡完全上皮化，其余40%患者的溃疡面积缩小。溃疡的上皮化与其初始大小有关。所取得的结果与使用类似的英国药物雷尼替丁所取得的结果没有差异。在使用雷尼替丁治疗过程中未观察到副作用。
