Brailski Kh, Mendizova A, Dimitrov B
Vutr Boles. 1984;23(1):23-8.
The results from the treatment with the preparation Zantac -Ranitidine of 30 patients with duodenal ulcers are reported. The treatment was carried out with 2 X 150 mg ranitidine daily for 20 days. As early as the second or third day after the initiation of the treatment, the pain disappeared in 96,6 per cent, the sense of heaviness and eructation -- in 100 per cent, pyrosis and palpation pain -- in 96,6 per cent an nausea - in 93,3 per cent. All indices of the gastric secretion (V, BAO, MAO and PAO) were reduced with a statistical significance after 20-day ranitidine treatment, as compared with the initial values. Epithelization (healing) of the ulcer was fibroendoscopically established in 73,3 per cent by 20th day, and by 40th -- in 93,3 per cent. The bigger ulcers were more slowly epithelized . Ranitidine was very well tolerated and gave no adverse effects. Better results, with a statistical significance, were obtained with ranitidine treatment of the duodenal ulcer, both as regards the effect on the subjective symptoms and epithelization of the ulcer as compared with the control group.
报告了用善胃得（雷尼替丁）制剂治疗30例十二指肠溃疡患者的结果。治疗方法为每日服用2次，每次150毫克雷尼替丁，持续20天。早在治疗开始后的第二天或第三天，96.6%的患者疼痛消失，100%的患者沉重感和嗳气消失，96.6%的患者烧心和触痛消失，93.3%的患者恶心消失。与初始值相比，经过20天的雷尼替丁治疗后，所有胃液分泌指标（V、基础胃酸排量、最大胃酸排量和高峰胃酸排量）均有统计学意义的降低。到第20天，通过纤维内镜检查发现73.3%的溃疡实现上皮化（愈合），到第40天，这一比例为93.3%。较大的溃疡上皮化较慢。雷尼替丁耐受性良好，无不良反应。与对照组相比，雷尼替丁治疗十二指肠溃疡在对主观症状的影响和溃疡上皮化方面均取得了具有统计学意义的更好结果。
