慢性乙型肝炎病毒感染者中 HMGB1 基因多态性。
HMGB1 gene polymorphisms in patients with chronic hepatitis B virus infection.
机构信息
Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
出版信息
World J Gastroenterol. 2013 Aug 21;19(31):5144-9. doi: 10.3748/wjg.v19.i31.5144.
Abstract
AIM
To characterize high mobility group box chromosomal protein 1 (HMGB1) polymorphisms in patients infected with hepatitis B virus (HBV) and determine the different patterns in patient subgroups.
METHODS
A total of 1495 unrelated Han Chinese HBV carriers were recruited in this hospital-based case-control study. The HMGB1 1176 G/C polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism assay.
RESULTS
A significant association was observed between HMGB1 1176 G/C polymorphism and outcome of HBV infection. The subjects bearing 1176G/G genotype had an increased risk of susceptibility to chronic hepatitis B, liver cirrhosis and severe hepatitis B when compared with those bearing at least one 1176C allele.
CONCLUSION
Patients with 1176G/G genotype of HMGB1 gene are more likely to have a progressive status in HBV infection.
摘要
目的
分析乙型肝炎病毒（HBV）感染者高迁移率族蛋白 B1（HMGB1）多态性，确定患者亚组中的不同模式。
方法
本研究采用基于医院的病例对照研究，共纳入 1495 例无关汉族 HBV 携带者。采用聚合酶链反应-限制性片段长度多态性分析方法对 HMGB1 1176 G/C 多态性进行基因分型。
结果
HMGB1 1176 G/C 多态性与 HBV 感染结局显著相关。与至少携带一个 1176C 等位基因的个体相比，携带 1176G/G 基因型的个体发生慢性乙型肝炎、肝硬化和重型乙型肝炎的易感性增加。
结论
HMGB1 基因 1176G/G 基因型的患者更有可能在 HBV 感染中出现进展状态。
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