紫苏油对小鼠血浆中心血管保护（n-3）脂肪酸浓度及血脂谱的影响。
Effects of perilla oil on plasma concentrations of cardioprotective (n-3) fatty acids and lipid profiles in mice.
机构信息
Department of Food and Nutrition, Sahmyook University, 815, Hwarang-ro, Nowon-gu, Seoul 139-742, Korea.
出版信息
Nutr Res Pract. 2013 Aug;7(4):256-61. doi: 10.4162/nrp.2013.7.4.256. Epub 2013 Aug 7.
Abstract
The aim of this study was to examine the effects of perilla oil as well as several vegetable oils, including flaxseed oil, canola oil, and rice bran oil on plasma levels of cardioprotective (n-3) polyunsaturated fatty acids in mice by feeding each vegetable oil for a period of eight weeks. Concentrations of docosapentaenoic acid (DHA) and eicosapentaenoic acid (EPA), fish-based (n-3) polyunsaturated fatty acids, showed an increase in the plasma of mice fed perilla and flaxseed oils compared to those of mice in the control group (P < 0.05), whereas rice bran and canola oils did not alter plasma DPA and EPA concentrations. Arachidonic acid concentration was increased by feeding rice bran oil (P < 0.05), but not canola, flaxseed, or perilla oil. In addition, oleic acid, linoleic acid, and docosahexaenoic acid concentrations were altered by feeding dietary rice bran, canola, perilla, and flaxseed oils. Findings of this study showed that perilla oil, similar to flaxseed oil, is cardioprotective and could be used as an alternative to fish oil or even flaxseed oil in animal models.
摘要
本研究旨在通过喂食每种植物油 8 周，研究紫苏油以及亚麻籽油、菜籽油和米糠油等几种植物油对小鼠血浆中心血管保护（n-3）多不饱和脂肪酸水平的影响。与对照组相比，喂食紫苏油和亚麻籽油的小鼠血浆中二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）等基于鱼类的（n-3）多不饱和脂肪酸浓度升高（P<0.05），而米糠油和菜籽油则没有改变血浆 DPA 和 EPA 浓度。喂食米糠油会增加花生四烯酸浓度（P<0.05），但菜籽油、亚麻籽油或紫苏油则没有。此外，喂食米糠、菜籽油、紫苏油和亚麻籽油会改变油酸、亚油酸和二十二碳六烯酸的浓度。本研究结果表明，紫苏油与亚麻籽油一样具有心脏保护作用，可在动物模型中替代鱼油，甚至替代亚麻籽油。
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