CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr. Homi Bhabha Road, Pune, 411008, India.
Org Lett. 2013 Sep 6;15(17):4556-9. doi: 10.1021/ol402110e. Epub 2013 Aug 21.
The first total synthesis of hunanamycin A, an antibiotic natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core from a marine-derived Bacillus hunanensis, is disclosed. The present effort provides access to sufficient amounts of scarce hunanamycin A for further biological evaluation and confirmation of the assigned absolute configuration. In addition, four new analogues of the natural product are reported.
本文首次全合成了来自海洋来源的芽孢杆菌属（Bacillus hunanensis）的抗生素天然产物 hunanamycin A，其核心为吡啶并[1,2,3-de]喹喔啉-2,3-二酮。目前的工作为进一步的生物学评价和所分配的绝对构型的确认提供了足够数量的稀有 hunanamycin A。此外，还报道了该天然产物的四个新类似物。
