Department of Oncosurgery, First Affiliated Hospital of Medical School, Xi'an Jiaotong University , Xi'an , China.
Crit Rev Microbiol. 2014 Aug;40(3):225-35. doi: 10.3109/1040841X.2013.776511. Epub 2013 Aug 22.
In 1813, Vautier published his observation of tumor regression in patients who had suffered from gas gangrene. Since then, many publications have described the use of bacteria as antitumor therapy. For example, Bifidobacterium and Clostridium have been shown to selectively colonize tumors and to reduce tumor size. In addition, recent studies have focused on the use of genetic engineering to induce the expression of pro-drug converting enzymes, cytokines, specific antibodies, or suicide genes in tumor-colonizing bacteria. Moreover, some animal experiments have reported the treatment of tumors with engineered bacteria, and few side effects were observed. Therefore, based on these advances in tumor targeting therapy, bacteria may represent the next generation of cancer therapy.
1813 年，Vautier 发表了他对患有气性坏疽的患者肿瘤消退的观察结果。从那时起，许多出版物都描述了使用细菌作为抗肿瘤治疗的方法。例如，双歧杆菌和梭状芽孢杆菌已被证明可以选择性地定植于肿瘤并缩小肿瘤体积。此外，最近的研究集中在利用基因工程诱导在定植于肿瘤的细菌中表达前药转化酶、细胞因子、特异性抗体或自杀基因。此外，一些动物实验已经报道了用工程化细菌治疗肿瘤，并且观察到很少有副作用。因此，基于肿瘤靶向治疗的这些进展，细菌可能代表下一代癌症治疗方法。
