Türker R K, Kaymakcalan S, Ercan Z S
Arch Int Pharmacodyn Ther. 1975 Apr;214(2):254-62.
THC has an antagonistic effect against histamine on the isolated perfused guinea-pig lung and rabbit kidney. This antagonism seems to be a competitive one at the concentrations used and interacts with histamine at H1-receptors. THC also antagonizes the effect of acetylcholine, PGE2, angiotensis II and histamine in the isolated continuously superfused guinea-pig ileum by a non-competitive manner. The antagonism between THC and histamine on the isolated superfused rabbit aortic strips was found to be highly specific, since 100% relaxation was obtained when the muscle contracted by histamine but not by the equipotent doses of angiotensin II and noradrenaline. THC also causes a significant increase in survival time of guinea-pigs when the animals were exposed to histamine aerosol. These results indicate a specific antagonism of THC against histamine in the preparations used in this investigation.
四氢大麻酚（THC）对离体灌注的豚鼠肺和兔肾中的组胺具有拮抗作用。在所使用的浓度下，这种拮抗作用似乎是竞争性的，并且在H1受体处与组胺相互作用。四氢大麻酚还以非竞争性方式拮抗乙酰胆碱、前列腺素E2、血管紧张素II和组胺对离体持续灌注的豚鼠回肠的作用。发现四氢大麻酚与组胺对离体灌注兔主动脉条的拮抗作用具有高度特异性，因为当肌肉由组胺收缩时可获得100%的舒张，但由等效剂量的血管紧张素II和去甲肾上腺素收缩时则不然。当豚鼠暴露于组胺气雾剂时，四氢大麻酚还会显著延长其存活时间。这些结果表明，在本研究中使用的制剂中，四氢大麻酚对组胺具有特异性拮抗作用。
