Virginia Tech, USA.
Autism. 2014 May;18(4):362-9. doi: 10.1177/1362361313481287. Epub 2013 Aug 21.
Assessment of global functioning is an important consideration in treatment outcome research; yet, there is little guidance on its evidence-based assessment for children with autism spectrum disorders. This study investigated the utility and validity of clinician-rated global functioning using the Developmental Disability-Child Global Assessment Scale in a sample of higher functioning adolescents with autism spectrum disorders and comorbid anxiety disorders enrolled in a randomized controlled trial (n = 30). Pretreatment Developmental Disability-Child Global Assessment Scale scores correlated with severity of autism spectrum disorders core symptoms (r = -.388, p = .034), pragmatic communication (r = .407, p = .032), and verbal ability (r = .449, p = .013) and did not correlate with severity of anxiety symptoms or with parent-reported adaptive behavior. Change in Developmental Disability-Child Global Assessment Scale scores during treatment was associated with autism spectrum disorders symptomatic improvement (r = .414, p = .040) and with improved general communication (r = .499, p = .013). Results support the importance of assessing global functioning in addition to symptom change and treatment response in clinical trials.
对全球功能的评估是治疗结果研究中的一个重要考虑因素；然而，对于自闭症谱系障碍儿童，其基于证据的评估几乎没有指导。本研究在一项随机对照试验（n = 30）中，调查了临床医生评定的全球功能使用发育障碍-儿童全球评估量表（Developmental Disability-Child Global Assessment Scale）在具有自闭症谱系障碍和合并焦虑障碍的高功能青少年样本中的效用和有效性。治疗前发育障碍-儿童全球评估量表评分与自闭症谱系障碍核心症状的严重程度（r = -.388，p =.034）、语用沟通（r =.407，p =.032）和语言能力（r =.449，p =.013）相关，与焦虑症状的严重程度或家长报告的适应行为无关。治疗期间发育障碍-儿童全球评估量表评分的变化与自闭症谱系障碍症状的改善（r =.414，p =.040）和一般沟通能力的提高（r =.499，p =.013）相关。研究结果支持在临床试验中除了症状变化和治疗反应外，评估全球功能的重要性。
