Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.
Clin Transl Gastroenterol. 2013 Aug 22;4(8):e41. doi: 10.1038/ctg.2013.12.
Common genetic and environmental risk factors may explain the concurrent increase in the incidence of both inflammatory bowel disease (IBD) and asthma. We examined whether IBD in a parent is associated with an increased asthma risk in offspring.
This was a registry-based cohort study of all children born alive in Denmark in 1979-2009, followed through 2010. IBD and asthma were identified using hospital diagnoses; antiasthma medication was also used to identify asthma. We computed risk of asthma and estimated adjusted incidence rate ratios (aIRRs) with 95% confidence intervals (CIs) using Cox proportional-hazards regression. We evaluated asthma risk according to maternal and paternal IBD, Crohn's disease (CD), and ulcerative colitis (UC). Children without parental IBD were the comparison cohort for all comparisons.
We identified 1,845,281 children, of whom 14,952 (0.8%) had a parent with IBD. The 10-year risk of asthma was 6.9% among offspring of parents with CD, 5.6% among offspring of parents with UC, and 5.0% among offspring of parents without IBD. The aIRR for asthma associated with parental IBD was 0.98 (95% CI: 0.91-1.04). The aIRR was 1.09 (95% CI: 0.98-1.22) for parental CD and 0.92 (95% CI: 0.84-1.00) for parental UC. Results were similar regardless of parent of origin or inclusion of antiasthma medication to define asthma.
Our data do not provide evidence for an increased risk of asthma in offspring with a parental history of IBD.
常见的遗传和环境风险因素可能解释了炎症性肠病（IBD）和哮喘发病率的同时增加。我们研究了父母的 IBD 是否与子女患哮喘的风险增加有关。
这是一项基于登记的队列研究，纳入了 1979 年至 2009 年期间在丹麦出生的所有活产儿，并随访至 2010 年。通过医院诊断确定 IBD 和哮喘；抗哮喘药物也用于确定哮喘。我们使用 Cox 比例风险回归计算哮喘的风险，并估计调整后的发病率比（aIRR）及其 95%置信区间（CI）。我们根据母亲和父亲的 IBD、克罗恩病（CD）和溃疡性结肠炎（UC）评估哮喘风险。所有比较的对照队列均为无父母 IBD 的儿童。
我们共确定了 1845281 名儿童，其中 14952 名（0.8%）的父母患有 IBD。父母患有 CD 的子女 10 年内患哮喘的风险为 6.9%，父母患有 UC 的子女为 5.6%，父母无 IBD 的子女为 5.0%。与父母 IBD 相关的哮喘 aIRR 为 0.98（95%CI：0.91-1.04）。父母患有 CD 的 aIRR 为 1.09（95%CI：0.98-1.22），父母患有 UC 的 aIRR 为 0.92（95%CI：0.84-1.00）。无论父母来源或纳入抗哮喘药物定义哮喘，结果均相似。
我们的数据没有提供父母有 IBD 病史的子女患哮喘风险增加的证据。
