Andersen Ane Birgitte Telén, Erichsen Rune, Kappelman Michael David, Frøslev Trine, Ehrenstein Vera
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Department of Pediatrics, Division of Pediatric Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Clin Epidemiol. 2014 Dec 29;7:37-44. doi: 10.2147/CLEP.S73662. eCollection 2015.
The incidences of celiac disease (CD) and asthma are increasing and the two conditions are associated in individuals. Risk of asthma may be passed on to the next generation through shared risk factors. We examined whether parental CD is associated with risk of asthma in offspring.
We conducted a population-based Danish nationwide cohort study, using medical databases, covering the period 1 January 1979 to 31 December 2009. For each child with a parental history of CD, we randomly sampled 100 children without this history from the children born in the same calendar year. We used Cox proportional-hazards regression to estimate incidence rate ratios for asthma, adjusting for measured covariates.
We identified 1,107 children with a parental history of CD and 110,700 children without this parental history. During up to 32 years of follow-up, 6,125 children received a hospital diagnosis of asthma. The adjusted incidence rate ratio for asthma associated with a parental history of CD was 1.09 (95% confidence interval: 0.86-1.39) and was similar for maternal and paternal CD. Inclusion of asthma-medication in the definition of asthma did not substantially change the results.
There was no convincing evidence of an increased risk of asthma among offspring of parents with CD.
乳糜泻（CD）和哮喘的发病率正在上升，且在个体中这两种疾病存在关联。哮喘风险可能通过共同的风险因素传递给下一代。我们研究了父母患乳糜泻是否与子女患哮喘的风险相关。
我们利用医疗数据库开展了一项基于丹麦全国人口的队列研究，研究时段为1979年1月1日至2009年12月31日。对于每一位有父母患乳糜泻病史的儿童，我们从同年出生的儿童中随机抽取100名无此病史的儿童作为对照。我们使用Cox比例风险回归来估计哮喘的发病率比，并对测量的协变量进行调整。
我们确定了1107名有父母患乳糜泻病史的儿童和110700名无此父母病史的儿童。在长达32年的随访期间，6125名儿童被医院诊断为哮喘。与父母患乳糜泻病史相关的哮喘调整发病率比为1.09（95%置信区间：0.86 - 1.39），母亲和父亲患乳糜泻的情况相似。将哮喘用药纳入哮喘定义并未实质性改变结果。
没有令人信服的证据表明父母患乳糜泻的子女患哮喘的风险增加。
