Zedler Birk, von Lengerke Thomas, Emeny Rebecca, Heier Margit, Lacruz Maria Elena, Ladwig Karl-Heinz
Forschungs- und Lehreinheit Medizinische Psychologie, Medizinische Hochschule Hannover.
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt, Institut für Epidemiologie II, Neuherberg.
Psychother Psychosom Med Psychol. 2014 Mar;64(3-4):128-35. doi: 10.1055/s-0033-1349097. Epub 2013 Aug 21.
This study examines differences in the rates of depression and anxiety symptoms in overweight vs. normal weight women before and after the menopause. In a population sample of 1 416 participants of the KORA-Survey F3 2004-2005 (age 35-74 years), body mass index (BMI), waist circumference (WC), waist-to-hip-ratio (WHR) und waist-to-height-ratio (WHtR) were measured via physical examination. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale. Compared with normal weight, obesity was associated with depression in premenopausal women. This held for elevated BMI-, WC- and WHtR-scores (OR=3.7, 4.2, and 2.8), underlining the relevance of both general and abdominal obesity. Menopausal status may be a moderator for the association of obesity and depression, which - given the interaction between these 2 risk factors - may be of preventive importance in regard to the development of cardiovascular outcomes such as coronary heart disease.
本研究调查了超重和正常体重女性在绝经前后抑郁和焦虑症状发生率的差异。在2004 - 2005年KORA调查F3的1416名参与者（年龄35 - 74岁）的人群样本中，通过体格检查测量了体重指数（BMI）、腰围（WC）、腰臀比（WHR）和腰高比（WHtR）。使用医院焦虑抑郁量表评估抑郁和焦虑情况。与正常体重相比，肥胖与绝经前女性的抑郁有关。这在BMI、WC和WHtR得分升高时成立（OR = 3.7、4.2和2.8），强调了全身性肥胖和腹部肥胖的相关性。绝经状态可能是肥胖与抑郁关联的调节因素，鉴于这两个危险因素之间的相互作用，这可能对冠心病等心血管疾病的发生具有预防意义。
