Walecka-Kapica Ewa, Chojnacki Jan, Stępień Agnieszka, Wachowska-Kelly Patrycja, Klupińska Grażyna, Chojnacki Cezary
Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University, 1 Haller's Square, 90-647 Lodz, Poland.
Int J Mol Sci. 2015 Jan 5;16(1):1030-42. doi: 10.3390/ijms16011030.
Estrogen deficiency is considered to be the main cause of increased appetite and increased weight in postmenopausal women. In this period, reduced secretion of melatonin (MEL) was also observed. The aim of the study was to evaluate the secretion of melatonin, 17-β estradiol and follicle-stimulating hormone (FSH) in relation to body mass index (BMI) in pre- and postmenopausal women. The study included 90 women divided into three equal groups: group I (control)-women without menstrual disorders, group II-postmenopausal women without change in appetite and body weight, group III-postmenopausal women experiencing increased appetite and weight gain. In each patient, serum melatonin, 17-β-estradiol, FSH and urine a 6-sulfatoxymelatonin (aMT6s) were determined. Compared to the control group, the level of melatonin and estradiol was statistically lower. The FSH level was higher than in the groups of postmenopausal women. No significant correlation was found in all groups between the level of melatonin and the levels of estradiol and FSH. A negative correlation was found between aMT6s excretion and BMI, and a positive correlation between the level of FSH and BMI, mainly in overweight women. The obtained results indicate a significant effect of melatonin deficiency on the process of weight gain in postmenopausal women and justify its use in treatment of these disorders.
雌激素缺乏被认为是绝经后女性食欲增加和体重上升的主要原因。在此期间，还观察到褪黑素（MEL）分泌减少。本研究的目的是评估绝经前和绝经后女性中褪黑素、17-β雌二醇和促卵泡激素（FSH）的分泌与体重指数（BMI）之间的关系。该研究纳入了90名女性，平均分为三组：第一组（对照组）——无月经紊乱的女性；第二组——食欲和体重无变化的绝经后女性；第三组——食欲增加且体重增加的绝经后女性。测定了每位患者血清中的褪黑素、17-β-雌二醇、FSH以及尿液中的6-硫酸氧褪黑素（aMT6s）。与对照组相比，褪黑素和雌二醇水平在统计学上较低。FSH水平高于绝经后女性组。在所有组中，褪黑素水平与雌二醇和FSH水平之间均未发现显著相关性。主要在超重女性中发现aMT6s排泄与BMI呈负相关，FSH水平与BMI呈正相关。所得结果表明褪黑素缺乏对绝经后女性体重增加过程有显著影响，并证明其在治疗这些病症中的应用价值。
