Departament de Física Fonamental, Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.
J R Soc Interface. 2013 Aug 21;10(88):20130581. doi: 10.1098/rsif.2013.0581. Print 2013 Nov 6.
We present a minimal motif model for transmembrane cell signalling. The model assumes signalling events taking place in spatially distributed nanoclusters regulated by a birth/death dynamics. The combination of these spatio-temporal aspects can be modulated to provide a robust and high-fidelity response behaviour without invoking sophisticated modelling of the signalling process as a sequence of cascade reactions and fine-tuned parameters. Our results show that the fact that the distributed signalling events take place in nanoclusters with a finite lifetime regulated by local production is sufficient to obtain a robust and high-fidelity response.
我们提出了一个用于跨膜细胞信号转导的最小基序模型。该模型假设信号事件发生在由出生/死亡动力学调节的空间分布的纳米簇中。通过组合这些时空方面，可以进行调制，以提供稳健且高保真的响应行为，而无需对信号转导过程进行复杂的级联反应序列建模和精细参数调整。我们的结果表明，分布的信号事件发生在由局部产生调节的具有有限寿命的纳米簇中的事实足以获得稳健且高保真的响应。
