抗生素的生物作用。
Biotic acts of antibiotics.
机构信息
Faculty of Medical Sciences, University of the West Indies Kingston, Jamaica.
出版信息
Front Microbiol. 2013 Aug 19;4:241. doi: 10.3389/fmicb.2013.00241. eCollection 2013.
Abstract
Biological functions of antibiotics are not limited to killing. The most likely function of antibiotics in natural microbial ecosystems is signaling. Does this signaling function of antibiotics also extend to the eukaryotic - in particular mammalian - cells? In this review, the host modulating properties of three classes of antibiotics (macrolides, tetracyclines, and β-lactams) will be briefly discussed. Antibiotics can be effective in treatment of a broad spectrum of diseases and pathological conditions other than those of infectious etiology and, in this capacity, may find widespread applications beyond the intended antimicrobial use. This use, however, should not compromise the primary function antibiotics are used for. The biological background for this inter-kingdom signaling is also discussed.
摘要
抗生素的生物学功能不仅限于杀菌。抗生素在自然微生物生态系统中最有可能的功能是信号传递。抗生素的这种信号传递功能是否也延伸到真核生物——特别是哺乳动物——细胞？在这篇综述中，将简要讨论三类抗生素（大环内酯类、四环素类和β-内酰胺类）的宿主调节特性。抗生素在治疗除感染病因以外的广泛疾病和病理状况方面非常有效，并且在这种能力方面，可能会在预期的抗菌用途之外得到广泛应用。然而，这种用途不应损害抗生素的主要功能。还讨论了这种跨王国信号传递的生物学背景。
相似文献
1
Biotic acts of antibiotics.抗生素的生物作用。
Front Microbiol. 2013 Aug 19;4:241. doi: 10.3389/fmicb.2013.00241. eCollection 2013.
2
3
Physicochemical properties of antibiotics: A review with an emphasis on detection in the aquatic environment.抗生素的物理化学性质：综述，重点关注其在水环境中的检测。
Water Environ Res. 2020 Feb;92(2):177-188. doi: 10.1002/wer.1237. Epub 2019 Sep 24.
4
[Genetic and biochemical basis of microbial resistance to antibiotics].[微生物对抗生素耐药性的遗传和生化基础]
Lijec Vjesn. 1990 Jul-Aug;112(7-8):250-7.
5
Total synthesis of the big four antibiotics and related antibiotics.四大抗生素及其相关抗生素的全合成。
J Antibiot (Tokyo). 2013 Mar;66(3):107-29. doi: 10.1038/ja.2012.126.
6
Interaction of swine organic anion transporting polypeptide 1a2 with tetracycline, macrolide and β-lactam antibiotics.猪有机阴离子转运多肽 1a2 与四环素、大环内酯类和β-内酰胺类抗生素的相互作用。
Toxicol Appl Pharmacol. 2019 Sep 15;379:114649. doi: 10.1016/j.taap.2019.114649. Epub 2019 Jul 6.
7
[Clinical and bacteriological studies of Streptococcus pneumoniae. Yearly changes in isolation frequencies from clinical specimens, serotype distributions and drug susceptibilities, especially those of beta-lactam-resistant strains].肺炎链球菌的临床与细菌学研究。临床标本分离频率、血清型分布及药敏情况的年度变化，尤其是耐β-内酰胺菌株的相关情况
Jpn J Antibiot. 1986 Mar;39(3):783-806.
8
Hypersensitivity reactions to non-beta-lactam antibiotics.对非β-内酰胺类抗生素的超敏反应。
Clin Rev Allergy Immunol. 2003 Jun;24(3):221-8. doi: 10.1385/CRIAI:24:3:221.
9
In vitro susceptibility of Chlamydia pecorum to macrolides, tetracyclines, quinolones and beta-lactam.
Microbiol Immunol. 1998;42(1):61-3. doi: 10.1111/j.1348-0421.1998.tb01971.x.
10
History of antimicrobial drug discovery: Major classes and health impact.抗菌药物发现的历史：主要类别和健康影响。
Biochem Pharmacol. 2017 Jun 1;133:4-19. doi: 10.1016/j.bcp.2016.10.001. Epub 2016 Oct 5.
引用本文的文献
1
Menadione as Antibiotic Adjuvant Against : Mechanism of Action, Efficacy and Safety.维生素K3作为抗生素辅助剂的作用机制、疗效及安全性
Antibiotics (Basel). 2025 Feb 7;14(2):163. doi: 10.3390/antibiotics14020163.
2
Aluminium-doped Carbon Dots for the Simultaneous Selective Detection of Five Tetracycline Antibiotics.用于同时选择性检测五种四环素类抗生素的铝掺杂碳点
J Fluoresc. 2025 May;35(5):3071-3081. doi: 10.1007/s10895-024-03738-1. Epub 2024 May 8.
3
Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets.对感染的全身反应会导致长期认知衰退：以神经炎症和氧化应激作为治疗靶点
Front Neurosci. 2022 Feb 18;15:742158. doi: 10.3389/fnins.2021.742158. eCollection 2021.
4
Clinical Biofilm Ring Test Reveals the Potential Role of β-Lactams in the Induction of Biofilm Formation by in Cystic Fibrosis Patients.临床生物膜环试验揭示了β-内酰胺类药物在囊性纤维化患者中诱导生物膜形成的潜在作用。
Pathogens. 2020 Dec 19;9(12):1065. doi: 10.3390/pathogens9121065.
5
Study of the structural, chemical descriptors and optoelectronic properties of the drugs Hydroxychloroquine and Azithromycin.羟氯喹啉和阿奇霉素的结构、化学描述符及光电性质研究
Heliyon. 2020 Aug 11;6(8):e04647. doi: 10.1016/j.heliyon.2020.e04647. eCollection 2020 Aug.
6
Environmental Triggers of Autoreactive Responses: Induction of Antiphospholipid Antibody Formation.环境触发自身反应：抗磷脂抗体形成的诱导。
Front Immunol. 2019 Jul 10;10:1609. doi: 10.3389/fimmu.2019.01609. eCollection 2019.
7
Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity.红霉素通过生长激素释放肽受体发挥作用，以减轻软骨细胞的炎症反应，维持关节完整性。
Biochem Pharmacol. 2019 Jul;165:79-90. doi: 10.1016/j.bcp.2019.03.014. Epub 2019 Mar 9.
8
Exploration of the Biosynthetic Potential of the Microbiome.微生物组生物合成潜力的探索
mSystems. 2018 Oct 2;3(5). doi: 10.1128/mSystems.00045-18. eCollection 2018 Sep-Oct.
9
PA5470 Counteracts Antimicrobial Effect of Azithromycin by Releasing Stalled Ribosome in Pseudomonas aeruginosa.PA5470 通过释放铜绿假单胞菌中停滞的核糖体来对抗阿奇霉素的抗菌作用。
Antimicrob Agents Chemother. 2018 Jan 25;62(2). doi: 10.1128/AAC.01867-17. Print 2018 Feb.
10
Editorial: Phage Therapy: Past, Present and Future.社论：噬菌体疗法：过去、现在与未来
Front Microbiol. 2017 Jun 15;8:981. doi: 10.3389/fmicb.2017.00981. eCollection 2017.
本文引用的文献
1
Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation.米诺环素通过抑制星形胶质细胞活化改善老年小鼠术后认知功能障碍。
Neuroreport. 2014 Jan 8;25(1):1-6. doi: 10.1097/WNR.0000000000000082.
2
Evolution in action: dissemination of tet(X) into pathogenic microbiota.实际发生的进化：tet(X)在致病微生物群中的传播
Front Microbiol. 2013 Jul 10;4:192. doi: 10.3389/fmicb.2013.00192. eCollection 2013.
3
Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse.mTORC1 抑制破坏与酒精相关的记忆可预防复发。
Nat Neurosci. 2013 Aug;16(8):1111-7. doi: 10.1038/nn.3439. Epub 2013 Jun 23.
4
Inhibitory impacts of chemically modified tetracycline-3 and underlying mechanism in human cervical cancer cells.化学修饰的四环素-3 的抑制作用及其在人宫颈癌细胞中的作用机制。
Anticancer Drugs. 2013 Sep;24(8):799-809. doi: 10.1097/CAD.0b013e328362b1be.
5
Microglia and synapse interactions: fine tuning neural circuits and candidate molecules.小胶质细胞与突触相互作用：神经回路的精细调节及候选分子。
Front Cell Neurosci. 2013 May 15;7:70. doi: 10.3389/fncel.2013.00070. eCollection 2013.
6
Microglia during development and aging.发育与衰老过程中的小胶质细胞。
Pharmacol Ther. 2013 Sep;139(3):313-26. doi: 10.1016/j.pharmthera.2013.04.013. Epub 2013 Apr 30.
7
Gut microbiota composition modifies fecal metabolic profiles in mice.肠道微生物组成改变了小鼠粪便中的代谢谱。
J Proteome Res. 2013 Jun 7;12(6):2987-99. doi: 10.1021/pr400263n. Epub 2013 May 10.
8
Minocycline attenuates cognitive impairment induced by isoflurane anesthesia in aged rats.米诺环素可减轻老龄大鼠异氟醚麻醉诱导的认知功能障碍。
PLoS One. 2013 Apr 17;8(4):e61385. doi: 10.1371/journal.pone.0061385. Print 2013.
9
Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis.多相随机对照试验中头孢曲松治疗肌萎缩侧索硬化症的设计和初步结果。
PLoS One. 2013 Apr 17;8(4):e61177. doi: 10.1371/journal.pone.0061177. Print 2013.
10
Minocycline, a microglial inhibitor, reduces 'honey trap' risk in human economic exchange.米诺环素，一种小胶质细胞抑制剂，降低了人类经济交换中的“美人陷阱”风险。
Sci Rep. 2013;3:1685. doi: 10.1038/srep01685.
Zotero 插件