Division of Pediatric Hematology/Oncology, Department of Pediatrics, The Children's Hospital at Montefiore, The Albert Einstein College of Medicine of Yeshiva University , Bronx, NY , USA ; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center , New York, NY , USA.
Front Oncol. 2013 Aug 14;3:210. doi: 10.3389/fonc.2013.00210. eCollection 2013.
Although functional differences have been described between patients with lower extremity bone sarcoma with amputation and limb-preservation surgery, differences have not clearly been shown between the two groups related to quality of life. The purpose of the study was to determine if there is a difference in overall quality of life in lower extremity bone sarcoma survivors related to whether they had an amputation or a limb-preservation procedure while identifying psychological differences for further evaluation. The main hypothesis was that sparing a person's limb, as opposed to amputating it, would result in a better quality of life.
Eighty-two long-term survivors of lower extremity bone sarcoma were studied to make a comparison of the overall quality of life, pain assessment, and psychological evaluations in limb preservation and amputation patients. Forty-eight patients with limb preservation and thirty-four patients with amputations were enrolled in the study. Validated psychometric measures including the Quality of Life Questionnaire (QLQ), the Minnesota Multiphasic Personality Inventory, and visual analog scales were utilized.
The overall quality of life of patients with limb preservation was significantly higher than patients with amputation (p-value < 0.01). Significant differences were noted in the categories of material well-being, job satisfiers, and occupational relations.
The overall quality of life of patients with limb-preservation appears to be better than for those patients with amputation based on the QLQ in patients surviving lower extremity bone sarcoma. Further analysis needs to verify the results and focus on the categories that significantly affect the overall quality of life.
尽管已经描述了下肢骨肉瘤截肢患者与保肢手术患者之间的功能差异，但在与生活质量相关的两组患者之间并未清楚地显示出差异。本研究的目的是确定下肢骨肉瘤幸存者的整体生活质量是否与是否进行截肢或保肢手术有关，同时确定进一步评估的心理差异。主要假设是，保留肢体而不是截肢会带来更好的生活质量。
研究了 82 例下肢骨肉瘤的长期幸存者，以比较保肢和截肢患者的整体生活质量、疼痛评估和心理评估。研究纳入了 48 例保肢患者和 34 例截肢患者。使用了经过验证的心理计量学测量方法，包括生活质量问卷（QLQ）、明尼苏达多相人格问卷和视觉模拟量表。
保肢患者的整体生活质量明显高于截肢患者（p 值<0.01）。在物质福利、工作满意度和职业关系等方面存在显著差异。
基于 QLQ，保肢患者的整体生活质量似乎优于截肢患者，这表明下肢骨肉瘤存活患者的生活质量更好。需要进一步分析来验证结果，并关注对整体生活质量有显著影响的类别。
