Okumura Chikara, Haraikawa Kaho, Suehiro Satomi, Ito Yuki, Masumoto Junya
Nihon Rinsho. 2013 Aug;71(8):1497-504.
Inflammation is a protective response intended to eliminate primary causes of tissue injury, leading to tissue repair and adaptation in a focal lesion. It is thought that various factors are involved in the histopathological responses to tissue injury. One of the inflammatory cytokines, interleukin(IL)-1beta, is thought to play an important role in inflammatory responses. The inflammasome is a multi-protein complex, required for IL-1beta processing and activation to induce inflammation. Over the past decade, evidence has accumulated that the inflammasome contributes significantly to the pathogenesis of various diseases. In this review, we discuss the function of inflammasome and inflammasome-related diseases, that are now expanding beyond inflammation.
炎症是一种旨在消除组织损伤主要原因的保护性反应，可导致局灶性病变的组织修复和适应。人们认为多种因素参与了对组织损伤的组织病理学反应。炎症细胞因子白细胞介素（IL）-1β被认为在炎症反应中起重要作用。炎性小体是一种多蛋白复合物，是IL-1β加工和激活以诱导炎症所必需的。在过去十年中，越来越多的证据表明炎性小体在各种疾病的发病机制中起重要作用。在本综述中，我们讨论了炎性小体的功能以及与炎性小体相关的疾病，这些疾病现在已超出炎症范畴。
