用于与人类胎儿成骨细胞结合的生物材料的表面改性。
Surface modification of biomaterials for conjugation with human fetal osteoblasts.
作者信息
Borcard Françoise, Kong Phally, Journot Céline, Staedler Davide, Sturzenegger Philip N, Juillerat Franziska Krauss, Gonzenbach Urs T, Juillerat-Jeanneret Lucienne, Gerber-Lemaire Sandrine
机构信息
Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne.
出版信息
Chimia (Aarau). 2013;67(4):213-7. doi: 10.2533/chimia.2013.213.
Surface functionalization of hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.
通过含邻苯三酚部分的化学配体对羟基磷灰石（HA）和β-磷酸三钙（TCP）生物陶瓷进行表面功能化处理，以提高骨细胞前体与生物材料的粘附性。与叠氮基修饰的人胎儿成骨细胞进行快速且生物相容的无铜点击反应，可改善细胞与HA和TCP生物陶瓷的结合，为在制备细胞工程骨植入物中使用该方法开辟了道路。
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