1Department of Pediatrics, Division of Pediatric Neurology, Cukurova University , Adana , Turkey.
Int J Neurosci. 2014 Apr;124(4):302-6. doi: 10.3109/00207454.2013.836706. Epub 2013 Oct 2.
Hashimoto's encephalopathy is a rare clinically heterogenous condition consisting of encephalopathy, seizures and variable neurological and psychiatric manifestations, accompanied by high titres of serum antithyroid antibodies. We described the clinical and laboratory findings of four children (aged 8-17 years) with Hashimoto's encephalopathy. The clinical features of three patients at presentation included refractory epilepsy, and confusion, and one patient presented with behavioral and cognitive changes. During their presentation, two of them were in euthyroid, and the others were in hypothyroid status. All patients manifested increased antithyroid antibodies. Two patients improved with steroid treatment. The others responded to plasmapheresis instead of corticosteroid treatment. Physicians' awareness of this complication is of great importance because most patients respond dramatically to the treatment.
桥本脑病是一种罕见的临床异质性疾病，由脑病、癫痫发作和多种神经精神表现组成，伴有高滴度的血清抗甲状腺抗体。我们描述了 4 名桥本脑病儿童（8-17 岁）的临床和实验室发现。3 名患者在就诊时的临床特征包括难治性癫痫、意识混乱，1 名患者表现为行为和认知改变。在就诊时，其中 2 名患者处于甲状腺功能正常，另外 2 名患者处于甲状腺功能减退状态。所有患者均表现出抗甲状腺抗体增加。2 名患者接受类固醇治疗后改善。其他患者对血浆置换治疗有反应，而不是对皮质类固醇治疗有反应。医生对这种并发症的认识非常重要，因为大多数患者对治疗有明显反应。
