University of California, Davis.
J Cogn Neurosci. 1997 Jan;9(1):143-59. doi: 10.1162/jocn.1997.9.1.143.
Three patients with complete resection of the corpus callosum were tested in a series of memory tasks to determine the effects of callosotomy on the encoding and retrieval of information in memory. Verbal and pictorial conjunction tests were administered to measure patients' ability to consolidate the elements of a stimulus into an accurate composite memory. Patients were also tested in a paired-associate learning task to determine the consequences of callosotomy on the encoding and retrieval of associations between stimuli. Although callosotomy patients were unimpaired in the verbal conjunction task, results from both the pictorial conjunction task and the paired-associate learning task suggest that the absence of callosal cross-talk impairs encoding in these patients. In addition, the pattern of results in the paired-associate learning task suggests that callosotomy impairs retrieval processes. The role of the callosum in the formation of memory traces for nonverbal material and associations between verbal stimuli is discussed.
三位胼胝体全切除术患者接受了一系列记忆任务测试，以确定胼胝体切开术对记忆中信息编码和提取的影响。进行了言语和图像联合测试，以衡量患者将刺激的元素整合到准确的综合记忆中的能力。还对患者进行了配对联想学习任务测试，以确定胼胝体切开术对刺激之间的联想编码和提取的后果。尽管胼胝体切开术患者在言语联合任务中没有受到影响，但来自图像联合任务和配对联想学习任务的结果表明，缺乏胼胝体交叉对话会损害这些患者的编码能力。此外，配对联想学习任务的结果模式表明胼胝体切开术会损害检索过程。讨论了胼胝体在形成非言语材料的记忆痕迹和言语刺激之间的联想中的作用。
