School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, HONG KONG.
Curr Protein Pept Sci. 2013 Sep;14(6):492-503. doi: 10.2174/13892037113149990066.
This review mainly summarizes results of recent studies on the anticancer activity of the multifunctional protein lactoferrin (Lf) and its derived peptide lactoferricin (Lfcin). The basic information on Lf and Lfcin, such as their sources, structures, and biological properties which favor their antitumor activity is introduced. The major anticancer mechanisms of Lf and Lfcin including cell cycle arrest, apoptosis, anti-angiogenesis, antimetastasis, immune modulation and necrosis are discussed. Other information from in vivo studies employing a mouse model is also provided. In addition, the roles of talatoferrin and delta lactoferrin, as well as improvement in drug delivery will be covered.
这篇综述主要总结了多功能蛋白乳铁蛋白（Lf）及其衍生肽乳铁蛋白肽（Lfcin）的抗癌活性的最新研究结果。介绍了 Lf 和 Lfcin 的基本信息，如它们的来源、结构和有利于其抗肿瘤活性的生物学特性。讨论了 Lf 和 Lfcin 的主要抗癌机制，包括细胞周期停滞、细胞凋亡、抗血管生成、抗转移、免疫调节和坏死。还提供了在小鼠模型中进行的体内研究的其他信息。此外，还将介绍talatoferrin 和 delta 乳铁蛋白的作用以及药物递送的改善。
