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Low NK cell counts in peripheral blood are associated with inferior overall survival in patients with follicular lymphoma.外周血中 NK 细胞计数低与滤泡性淋巴瘤患者的总生存预后不良相关。
Leuk Res. 2013 Oct;37(10):1213-5. doi: 10.1016/j.leukres.2013.07.038. Epub 2013 Aug 7.
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Low absolute CD4 T cell counts in peripheral blood are associated with inferior survival in follicular lymphoma.外周血中CD4 T细胞绝对计数低与滤泡性淋巴瘤患者较差的生存率相关。
Tumour Biol. 2016 Sep;37(9):12589-12595. doi: 10.1007/s13277-016-5124-9. Epub 2016 Jul 7.
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[Clinical Significance of Detecting CD4 T Cells in Peripheral Blood of Patients with Follicular lymphoma].[检测滤泡性淋巴瘤患者外周血中CD4 T细胞的临床意义]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Apr;25(2):449-454. doi: 10.7534/j.issn.1009-2137.2017.02.025.
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Low absolute NK cell counts in peripheral blood are associated with inferior survival in patients with mantle cell lymphoma.外周血中绝对 NK 细胞计数低与套细胞淋巴瘤患者的生存预后不良相关。
Cancer Biomark. 2019;24(4):439-447. doi: 10.3233/CBM-182193.
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Negative prognostic impact of low absolute CD4 T cell counts in peripheral blood in mantle cell lymphoma.套细胞淋巴瘤外周血中低绝对CD4 T细胞计数的不良预后影响
Cancer Sci. 2016 Oct;107(10):1471-1476. doi: 10.1111/cas.13020. Epub 2016 Sep 14.
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Ratio of peripheral blood absolute lymphocyte count to absolute monocyte count at diagnosis is associated with progression-free survival in follicular lymphoma.滤泡性淋巴瘤诊断时外周血绝对淋巴细胞计数与绝对单核细胞计数之比与无进展生存期相关。
Int J Hematol. 2014 Jun;99(6):737-42. doi: 10.1007/s12185-014-1576-0. Epub 2014 Apr 23.
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Low natural killer (NK) cell counts in peripheral blood adversely affect clinical outcome of patients with follicular lymphoma.外周血中自然杀伤（NK）细胞计数低会对滤泡性淋巴瘤患者的临床结局产生不利影响。
Blood Cancer J. 2016 Aug 12;6(8):e457. doi: 10.1038/bcj.2016.67.
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Absolute B cell counts in blood predict long-term response in follicular lymphoma patients treated with rituximab without chemotherapy.血液中的绝对 B 细胞计数可预测未经化疗而接受利妥昔单抗治疗的滤泡性淋巴瘤患者的长期反应。
Ann Hematol. 2020 Oct;99(10):2357-2366. doi: 10.1007/s00277-020-04208-x. Epub 2020 Aug 17.
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Low Level of Blood CD4 T Cells Is an Independent Predictor of Inferior Progression-free Survival in Diffuse Large B-cell Lymphoma.血液中CD4 T细胞水平低是弥漫性大B细胞淋巴瘤无进展生存期较差的独立预测因素。
Clin Lymphoma Myeloma Leuk. 2017 Feb;17(2):83-88. doi: 10.1016/j.clml.2016.11.005. Epub 2016 Nov 30.
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[Distribution of Natural Killer Cell in Patients with Newly Diagnosed Myelodysplastic Syndromes and Its Correlation with Prognosis].[初诊骨髓增生异常综合征患者自然杀伤细胞分布及其与预后的相关性]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Feb;28(1):196-201. doi: 10.19746/j.cnki.issn.1009-2137.2020.01.033.
引用本文的文献
1
Enhancement of NK Cell Cytotoxic Activity and Immunoregulatory Effects of a Natural Product Supplement Across a Wide Age Span: A 30-Day In Vivo Human Study.天然产物补充剂对不同年龄段自然杀伤细胞细胞毒性活性的增强作用及免疫调节效应：一项为期30天的人体体内研究
Int J Mol Sci. 2025 Mar 22;26(7):2897. doi: 10.3390/ijms26072897.
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Changes of T cell subsets across treatments associated with prognosis in newly diagnosed follicular lymphoma.治疗相关的 T 细胞亚群变化与新诊断滤泡性淋巴瘤的预后相关。
Sci Rep. 2024 Nov 11;14(1):27576. doi: 10.1038/s41598-024-79173-w.
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Natural Killer cells at the frontline in the fight against cancer.自然杀伤细胞在抗击癌症的第一线。
Cell Death Dis. 2024 Aug 23;15(8):614. doi: 10.1038/s41419-024-06976-0.
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Adaptive natural killer cell expression in response to cytomegalovirus infection in blood and solid cancer.血液和实体癌中巨细胞病毒感染后适应性自然杀伤细胞的表达
Heliyon. 2024 Jun 6;10(11):e32622. doi: 10.1016/j.heliyon.2024.e32622. eCollection 2024 Jun 15.
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Circulating Immune Cells Predict Prognosis and Clinical Response to Chemotherapy in Cholangiocarcinoma.循环免疫细胞可预测胆管癌的预后及对化疗的临床反应。
Curr Med Chem. 2025;32(3):595-607. doi: 10.2174/0109298673296618240424095548.
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Potent immunomodulatory and antitumor effect of anti-CD20-IL2no-alpha tri-functional immunocytokine for cancer therapy.抗 CD20-IL2no-α 三功能免疫细胞因子在癌症治疗中的强大免疫调节和抗肿瘤作用。
Front Immunol. 2022 Dec 9;13:1021828. doi: 10.3389/fimmu.2022.1021828. eCollection 2022.
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Cytokines and Lymphoid Populations as Potential Biomarkers in Locally and Borderline Pancreatic Adenocarcinoma.细胞因子和淋巴细胞群作为局部和临界性胰腺腺癌的潜在生物标志物
Cancers (Basel). 2022 Dec 5;14(23):5993. doi: 10.3390/cancers14235993.
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Role of the ITAM-Bearing Receptors Expressed by Natural Killer Cells in Cancer.自然杀伤细胞表达的含有免疫受体酪氨酸激活基序的受体在癌症中的作用。
Front Immunol. 2022 Jun 10;13:898745. doi: 10.3389/fimmu.2022.898745. eCollection 2022.
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Absolute Lymphocyte Counts After Lenalidomide Initiation may Predict the Prognosis of Patients With Relapsed or Refractory Multiple Myeloma.来那度胺起始治疗后的绝对淋巴细胞计数可能预测复发或难治性多发性骨髓瘤患者的预后。
Cancer Diagn Progn. 2021 Jul 3;1(3):221-229. doi: 10.21873/cdp.10030. eCollection 2021 Jul-Aug.
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Natural killer cells in cancer biology and therapy.自然杀伤细胞在癌症生物学和治疗中的作用。
Mol Cancer. 2020 Aug 6;19(1):120. doi: 10.1186/s12943-020-01238-x.
本文引用的文献
1
Blood lymphocyte-to-monocyte ratio identifies high-risk patients in diffuse large B-cell lymphoma treated with R-CHOP.血液淋巴细胞与单核细胞比值可识别接受 R-CHOP 治疗的弥漫性大 B 细胞淋巴瘤的高危患者。
PLoS One. 2012;7(7):e41658. doi: 10.1371/journal.pone.0041658. Epub 2012 Jul 23.
2
Entourage: the immune microenvironment following follicular lymphoma.伴生群集：滤泡性淋巴瘤的免疫微环境。
Blood Cancer J. 2012 Jan;2(1):e52. doi: 10.1038/bcj.2011.53. Epub 2012 Jan 20.
3
Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL.未治疗的惰性 B 细胞淋巴瘤和极早期 CLL 中系统性 T 细胞失调的定义和特征。
Blood. 2011 Apr 7;117(14):3836-46. doi: 10.1182/blood-2010-07-299321. Epub 2011 Jan 26.
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Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy.滤泡性淋巴瘤细胞诱导 T 细胞免疫突触功能障碍，来那度胺可修复该障碍：对肿瘤微环境和免疫治疗的影响。
Blood. 2009 Nov 19;114(21):4713-20. doi: 10.1182/blood-2009-04-217687. Epub 2009 Sep 28.
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Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project.滤泡性淋巴瘤国际预后指数2：由国际滤泡性淋巴瘤预后因素项目制定的滤泡性淋巴瘤新预后指数。
J Clin Oncol. 2009 Sep 20;27(27):4555-62. doi: 10.1200/JCO.2008.21.3991. Epub 2009 Aug 3.
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Impact of the tumor microenvironment on prognosis in follicular lymphoma is dependent on specific treatment protocols.肿瘤微环境对滤泡性淋巴瘤预后的影响取决于特定的治疗方案。
Haematologica. 2009 Jan;94(1):70-7. doi: 10.3324/haematol.13574. Epub 2008 Dec 4.
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Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells.滤泡性淋巴瘤B细胞可诱导常规CD4+ T细胞转化为调节性T细胞。
Int J Cancer. 2009 Jan 1;124(1):239-44. doi: 10.1002/ijc.23881.
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Human natural killer cells.人类自然杀伤细胞。
Blood. 2008 Aug 1;112(3):461-9. doi: 10.1182/blood-2007-09-077438.
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lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells.来那度胺增强利妥昔单抗治疗的CD20+肿瘤细胞的自然杀伤细胞和单核细胞介导的抗体依赖性细胞毒性。
Clin Cancer Res. 2008 Jul 15;14(14):4650-7. doi: 10.1158/1078-0432.CCR-07-4405.
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Claimed association of absolute lymphocyte count with therapeutic efficacy of radio-immunotherapy in patients with indolent lymphoma cannot be verified in an independent data set.
Leukemia. 2008 Dec;22(12):2259-60; author reply 2260-1. doi: 10.1038/leu.2008.116. Epub 2008 May 15.
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