IRMB, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, France.
Equipe TIRECs, Labellisée Ligue Contre le Cancer, Centre de Recherche INSERM CTM-UMR1231, Dijon, France.
Cell Death Dis. 2024 Aug 23;15(8):614. doi: 10.1038/s41419-024-06976-0.
Natural Killer (NK) cells are innate immune cells that play a pivotal role as first line defenders in the anti-tumor response. To prevent tumor development, NK cells are searching for abnormal cells within the body and appear to be key players in immunosurveillance. Upon recognition of abnormal cells, NK cells will become activated to destroy them. In order to fulfill their anti-tumoral function, they rely on the secretion of lytic granules, expression of death receptors and production of cytokines. Additionally, NK cells interact with other cells in the tumor microenvironment. In this review, we will first focus on NK cells' activation and cytotoxicity mechanisms as well as NK cells behavior during serial killing. Lastly, we will review NK cells' crosstalk with the other immune cells present in the tumor microenvironment.
自然杀伤 (NK) 细胞是先天免疫细胞，作为抗肿瘤反应的第一道防线，发挥着关键作用。为了防止肿瘤的发展，NK 细胞在体内寻找异常细胞，并且似乎是免疫监视的关键参与者。一旦识别出异常细胞，NK 细胞就会被激活并摧毁它们。为了发挥其抗肿瘤功能，NK 细胞依赖于裂解颗粒的分泌、死亡受体的表达和细胞因子的产生。此外，NK 细胞还与肿瘤微环境中的其他细胞相互作用。在这篇综述中，我们将首先关注 NK 细胞的激活和细胞毒性机制，以及 NK 细胞在连续杀伤过程中的行为。最后，我们将回顾 NK 细胞与肿瘤微环境中存在的其他免疫细胞的相互作用。
