外向-三亚甲基降冰片烷衍生物的合成及药理活性。V.
Synthesis and pharmacological activity of derivatives of exo-trimethylenenorbornane. V.
作者信息
Longobardi M, Schenone P, Bargagna A, Matera C, Rossi F, Marmo E
出版信息
Farmaco Sci. 1985 Mar;40(3):162-9.
PMID:4007150
Abstract
The synthesis of two series of amides and glycinamides starting from N-phenyl exo-5,6-trimethylenenorbornan-2-endo-amine, prepared from exo-5,6-trimethylenenorbornan-2-one via sodium borohydride reduction of its N-phenyl imine, is described. All amides showed a moderate hypotensive activity in rats, whereas some glycinamides and amides showed weak infiltration anesthesia and antiarrhythmic activity in mice. Effects on heart rate in rats are also reported.
摘要
描述了从 N-苯基外向-5,6-亚甲基降冰片烷-2-内型胺开始合成两个系列的酰胺和甘氨酰胺的过程，该胺由外向-5,6-亚甲基降冰片烷-2-酮通过其 N-苯基亚胺的硼氢化钠还原制备。所有酰胺在大鼠中均表现出适度的降压活性，而一些甘氨酰胺和酰胺在小鼠中表现出微弱的浸润麻醉和抗心律失常活性。还报道了对大鼠心率的影响。
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