Akelma A Z, Mete E, Cizmeci M N, Kanburoglu M K, Malli D D, Bozkaya D
Division of Pediatric Allergy, Department of Pediatrics, Turgut Ozal University Medical School, Ankara, Turkey.
Department of Pediatrics, Turgut Ozal University Medical School, Ankara, Turkey.
Allergol Immunopathol (Madr). 2015 Jan-Feb;43(1):10-3. doi: 10.1016/j.aller.2013.06.002. Epub 2013 Aug 20.
Previous studies have shown that platelets are involved in the inflammatory process. Mean platelet volume (MPV) has been frequently used as an inflammatory marker in various diseases associated with inflammation. The role of MPV in children with chronic spontaneous urticaria (CU), however, has not yet been evaluated. In this study we compared MPV levels between children with and without CU.
Children with CU and age-matched healthy children were enrolled in the study. Complete blood count and C-reactive protein (CRP) levels were assessed in children with CU whilst MPV levels were compared between children with and without CU.
Forty children with CU (19 males; mean age: 8.0 ± 3.8 year; range: 3-15 years) and 40 healthy children (17 males; mean age: 6.9 ± 3.0 year; range: 2-14 year) were enrolled on the prospective, case-control study. MPV (fL) levels were significantly lower in children with CU when compared to healthy children (7.42 ± 0.77 and 7.89 ± 0.65, respectively; p=0.004). Both mean platelet number and median CRP levels were significantly higher in children with CU when compared to healthy children (p=0.008, p=0.014, respectively).
To our knowledge, this study is the first to evaluate the role of MPV as an inflammatory marker in children with CU. A decline in MPV may be considered as an indicator of inflammation in children with CU.
既往研究表明血小板参与炎症过程。平均血小板体积（MPV）常被用作与炎症相关的各种疾病的炎症标志物。然而，MPV在慢性自发性荨麻疹（CU）患儿中的作用尚未得到评估。在本研究中，我们比较了CU患儿与非CU患儿的MPV水平。
将CU患儿和年龄匹配的健康儿童纳入研究。对CU患儿进行全血细胞计数和C反应蛋白（CRP）水平评估，同时比较CU患儿与非CU患儿的MPV水平。
40例CU患儿（19例男性；平均年龄：8.0±3.8岁；范围：3 - 15岁）和40例健康儿童（17例男性；平均年龄：6.9±3.0岁；范围：2 - 14岁）被纳入这项前瞻性病例对照研究。与健康儿童相比，CU患儿的MPV（fL）水平显著降低（分别为7.42±0.77和7.89±0.65；p = 0.004）。与健康儿童相比，CU患儿的平均血小板数量和CRP中位数水平均显著升高（分别为p = 0.008，p = 0.014）。
据我们所知，本研究首次评估了MPV作为炎症标志物在CU患儿中的作用。MPV下降可能被视为CU患儿炎症的一个指标。
