Vena Gino Antonio, Cassano Nicoletta, Marzano Angelo Valerio, Asero Riccardo
Dermatology and Venereology Private Practice, Bari and Barletta, Italy.
Int Arch Allergy Immunol. 2016;169(2):71-9. doi: 10.1159/000444085. Epub 2016 Apr 2.
Platelets are implicated in many pathophysiological processes, including inflammation and immunity. Ever-growing evidence suggests the active involvement of platelets in the pathogenesis of various inflammatory disorders, including cutaneous inflammatory diseases. A limited number of studies have investigated the role of platelets in chronic urticaria (CU). In this review, we summarize the current knowledge regarding the role of platelets in chronic spontaneous and inducible urticarias.
A literature search was performed using PubMed and Google Scholar, and the references of relevant literature were reviewed.
Overall, in CU patients, conflicting results have been obtained from the assessment of platelet indices, such as mean platelet volume, platelet count and distribution width, as well as markers of platelet aggregation and activation. Nevertheless, a few studies showed significant changes of such parameters in CU patients compared to controls, in apparent correlation with clinical severity, autoreactivity and/or inflammatory status.
In the absence of definitive conclusions, the pathogenic role of platelets in CU needs to be further explored. Platelets might represent a link between inflammation, coagulation and histamine release in the pathophysiological network of CU.
血小板参与许多病理生理过程，包括炎症和免疫。越来越多的证据表明血小板积极参与各种炎症性疾病的发病机制，包括皮肤炎症性疾病。少数研究调查了血小板在慢性荨麻疹（CU）中的作用。在本综述中，我们总结了关于血小板在慢性自发性和诱发性荨麻疹中作用的当前知识。
使用PubMed和谷歌学术进行文献检索，并查阅相关文献的参考文献。
总体而言，在CU患者中，对血小板指标（如平均血小板体积、血小板计数和分布宽度）以及血小板聚集和活化标志物的评估结果相互矛盾。然而，一些研究表明，与对照组相比，CU患者的这些参数有显著变化，这显然与临床严重程度、自身反应性和/或炎症状态相关。
在没有明确结论的情况下，血小板在CU中的致病作用需要进一步探索。血小板可能是CU病理生理网络中炎症、凝血和组胺释放之间的一个联系环节。
